TLK2
null TLK2 is the second tousled-like kinase in humans and shares with TLK1 the S phase-restricted activation and the phosphorylation of the histone chaperone ASF1 that couples DNA synthesis with nucleosome deposition. Genetic depletion of TLK2 compromises genome stability and cell proliferation, and the kinase shows synthetic lethal relationships with DNA repair defects. Amplification of the TLK2 locus with corresponding overexpression occurs in a subset of breast cancers, and the kinase has emerged as a candidate vulnerability in genomically unstable tumors. TLK2 mutations are also observed in neurodevelopmental disorder cohorts.
-
TLK2 組換えタンパク質 (1)
- 生物種:
- 由来:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 分子式: Human
- 分子量: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
