PSI
Based on 2 publication(s) in Google Scholar
PSI (Proteasome Inhibitor 1) is a potent proteasome inhibitor. PSI inhibits the proliferation of primary effusion lymphoma (PEL) cells. PSI has the potential for the research of Kaposi’s sarcoma-associated herpesvirus (KSHV) infection and KSHV-associated lymphomas.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.00%
- CAS 番号: 158442-41-2
- 分子式: C32H50N4O8
- 分子量:618.76
-
保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
-
HY-13259
MG-132Proteasome Inhibitor -
HY-19312
3-MethyladenineAutophagy/PI3K Inhibitor -
HY-18964
MG-101Cysteine Protease Inhibitor -
HY-13821
EpoxomicinProteasome Inhibitor -
HY-10455
CarfilzomibProteasome Inhibitor -
HY-13207
ONX-0914Proteasome Inhibitor -
HY-10454
DelanzomibProteasome Inhibitor -
HY-108552
MG-115Proteasome Inhibitor -
HY-10227
BortezomibProteasome Inhibitor -
HY-100558
Bafilomycin A1V-ATPase Inhibitor -
HY-16594
LactacystinProteasome Inhibitor -
HY-107412
Proteasome inhibitor IX20S Proteasome Inhibitor
MedChemExpress（MCE）の使用を引用している文献 PSI
More
生物活性
製品説明
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| PC-3 | IC50 |
375 nM
Compound: 3
|
Antiproliferative activity against human PC3 cell line
Antiproliferative activity against human PC3 cell line
|
[PMID: 16686537] |
体外実験
PSI (24 h) inhibits the proliferation of primary effusion lymphoma (PEL) cells at low nanomolar concentrations (CC50s of 205, 190, 22.0, 53.0 nM FOR BJAB, Ramos, BC3, BCBL1 cells, respectively)[1].
PSI (50 nM; 6 h) increases caspase-3/7 activity by 8-fold compared with control[1].
PSI (50 nM; 6 h) decreases the transcriptional activity of NF-κB by 52%[1].
PSI (1, 5 nM; 3 days) inhibits the growth of BC3 cells at a high concentration (5 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:BC3, BCBL1, Ramos, BJAB cells
-
Concentration:
-
Incubation Time:24 h
-
Result:Inhibited the proliferation of primary effusion lymphoma (PEL) cells at low nanomolar concentrations (CC50s of 205, 190, 22.0, 53.0 nM FOR BJAB, Ramos, BC3, BCBL1 cells, respectively).
-
Cell Line:HBL6 cells
-
Concentration:50 nM
-
Incubation Time:6 h
-
Result:Decreased the NF-κB activity by 52%.
化学情報
-
CAS 番号 158442-41-2
-
性状 Solid
-
分子量 618.76
-
分子式 C32H50N4O8
-
Color White to off-white
-
別名
Proteasome Inhibitor 1; Z-Ile-Glu(OtBu)-Ala-Leu-CHO
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
-
Journal Impact Factor
-
Most Recent
-
Signal Transduct Target Ther
Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]2025 Dec 15;10(1):406. PMID: 41392286 -
Br J Pharmacol
Fenofibrate potentiates the therapeutic efficacy of EZH2 inhibitors on melanoma via TRIM21- and OTUD4-mediated EZH2 ubiquitination. [Abstract]2026 Jun;183(11):2675-2694. PMID: 41652905
溶剤 & 溶解度
体外:
DMSO : ≥ 100 mg/mL (161.61 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : < 0.1 mg/mL (adjust pH to 2 with Acetic acid) (insoluble)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (274 KB)
-
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
-
取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6161 mL | 8.0807 mL | 16.1614 mL | 40.4034 mL |
| 5 mM | 0.3232 mL | 1.6161 mL | 3.2323 mL | 8.0807 mL | |
| 10 mM | 0.1616 mL | 0.8081 mL | 1.6161 mL | 4.0403 mL | |
| 15 mM | 0.1077 mL | 0.5387 mL | 1.0774 mL | 2.6936 mL | |
| 20 mM | 0.0808 mL | 0.4040 mL | 0.8081 mL | 2.0202 mL | |
| 25 mM | 0.0646 mL | 0.3232 mL | 0.6465 mL | 1.6161 mL | |
| 30 mM | 0.0539 mL | 0.2694 mL | 0.5387 mL | 1.3468 mL | |
| 40 mM | 0.0404 mL | 0.2020 mL | 0.4040 mL | 1.0101 mL | |
| 50 mM | 0.0323 mL | 0.1616 mL | 0.3232 mL | 0.8081 mL | |
| 60 mM | 0.0269 mL | 0.1347 mL | 0.2694 mL | 0.6734 mL | |
| 80 mM | 0.0202 mL | 0.1010 mL | 0.2020 mL | 0.5050 mL | |
| 100 mM | 0.0162 mL | 0.0808 mL | 0.1616 mL | 0.4040 mL |
PSI 関連分類
HY-P1258 関連分類
Powered by Bioz