PSI
Based on 2 publication(s) in Google Scholar
PSI (Proteasome Inhibitor 1) is a potent proteasome inhibitor. PSI inhibits the proliferation of primary effusion lymphoma (PEL) cells. PSI has the potential for the research of Kaposi’s sarcoma-associated herpesvirus (KSHV) infection and KSHV-associated lymphomas.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 158442-41-2
- 分子式: C32H50N4O8
- 分子量:618.76
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保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 PSI
More
生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| PC-3 | IC50 |
375 nM
Compound: 3
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Antiproliferative activity against human PC3 cell line
Antiproliferative activity against human PC3 cell line
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[PMID: 16686537] |
体外実験
PSI (24 h) inhibits the proliferation of primary effusion lymphoma (PEL) cells at low nanomolar concentrations (CC50s of 205, 190, 22.0, 53.0 nM FOR BJAB, Ramos, BC3, BCBL1 cells, respectively)[1].
PSI (50 nM; 6 h) increases caspase-3/7 activity by 8-fold compared with control[1].
PSI (50 nM; 6 h) decreases the transcriptional activity of NF-κB by 52%[1].
PSI (1, 5 nM; 3 days) inhibits the growth of BC3 cells at a high concentration (5 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:BC3, BCBL1, Ramos, BJAB cells
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Concentration:
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Incubation Time:24 h
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Result:Inhibited the proliferation of primary effusion lymphoma (PEL) cells at low nanomolar concentrations (CC50s of 205, 190, 22.0, 53.0 nM FOR BJAB, Ramos, BC3, BCBL1 cells, respectively).
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Cell Line:HBL6 cells
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Concentration:50 nM
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Incubation Time:6 h
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Result:Decreased the NF-κB activity by 52%.
化学情報
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CAS 番号 158442-41-2
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性状 Solid
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分子量 618.76
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分子式 C32H50N4O8
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Color White to off-white
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別名
Proteasome Inhibitor 1; Z-Ile-Glu(OtBu)-Ala-Leu-CHO
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]2025 Dec 15;10(1):406. PMID: 41392286 -
Br J Pharmacol
Fenofibrate potentiates the therapeutic efficacy of EZH2 inhibitors on melanoma via TRIM21- and OTUD4-mediated EZH2 ubiquitination. [Abstract]2026 Jun;183(11):2675-2694. PMID: 41652905
溶剤 & 溶解度
体外:
H2O : < 0.1 mg/mL (adjust pH to 2 with Acetic acid) (insoluble)
純度とドキュメンテーション
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データシート (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
PSI 関連分類
HY-P1258 関連分類
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