Raluridine
Based on 1 Customer Validation
Raluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.53%
- CAS 番号: 119644-22-3
- 分子式: C9H10ClFN2O4
- 分子量:264.64
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CCRF-CEM | CC50 |
188 μM
Compound: 1h; FddClU
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Cytotoxicity in human CEM/0 cells assessed as reduction in cell viability incubated for 4 to 5 days
Cytotoxicity in human CEM/0 cells assessed as reduction in cell viability incubated for 4 to 5 days
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[PMID: 32515595] |
| MT4 | ED50 |
0.38 μM
Compound: 11 (FddClUrd)
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Effective dose achieving 50% protection of MT-4 cells against the cytopathic effect of HIV
Effective dose achieving 50% protection of MT-4 cells against the cytopathic effect of HIV
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[PMID: 2342078] |
| MT4 | ED50 |
0.38 μM
Compound: 17a
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Inhibitory activity against HIV-1 replication in MT-4 cells
Inhibitory activity against HIV-1 replication in MT-4 cells
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[PMID: 2754700] |
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 119644-22-3
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性状 Solid
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分子量 264.64
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分子式 C9H10ClFN2O4
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Color White to off-white
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SMILES
OC[C@@H]1[C@@H](F)C[C@H](N2C(NC(C(Cl)=C2)=O)=O)O1
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別名
935U83
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外:
DMSO : 250 mg/mL (944.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7787 mL | 18.8936 mL | 37.7872 mL | 94.4680 mL |
| 5 mM | 0.7557 mL | 3.7787 mL | 7.5574 mL | 18.8936 mL | |
| 10 mM | 0.3779 mL | 1.8894 mL | 3.7787 mL | 9.4468 mL | |
| 15 mM | 0.2519 mL | 1.2596 mL | 2.5191 mL | 6.2979 mL | |
| 20 mM | 0.1889 mL | 0.9447 mL | 1.8894 mL | 4.7234 mL | |
| 25 mM | 0.1511 mL | 0.7557 mL | 1.5115 mL | 3.7787 mL | |
| 30 mM | 0.1260 mL | 0.6298 mL | 1.2596 mL | 3.1489 mL | |
| 40 mM | 0.0945 mL | 0.4723 mL | 0.9447 mL | 2.3617 mL | |
| 50 mM | 0.0756 mL | 0.3779 mL | 0.7557 mL | 1.8894 mL | |
| 60 mM | 0.0630 mL | 0.3149 mL | 0.6298 mL | 1.5745 mL | |
| 80 mM | 0.0472 mL | 0.2362 mL | 0.4723 mL | 1.1808 mL | |
| 100 mM | 0.0378 mL | 0.1889 mL | 0.3779 mL | 0.9447 mL |
Raluridine 関連分類
HY-124092 関連分類
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