RBWH15
RBWH15 is a synthetic broad-spectrum antimicrobial peptide. RBWH15 increases the permeability of bacterial outer and inner membranes, disrupts membrane integrity and induces bacterial death. RBWH15 exhibits biofilm eradication activity and can eliminate established bacterial biofilms. RBWH15 shows broad-spectrum antimicrobial activity against Gram-negative and Gram-positive ESKAPE pathogens, including multidrug-resistant strains. RBWH15 can be used in the research of multidrug-resistant bacterial infections.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C79H143N19O14
- 分子量:1583.10
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
RBWH15 (0.375-18 μM, >200 μM; 18-24 h) potently inhibits the growth of multiple Gram-positive and Gram-negative ESKAPE pathogens, including methicillin-resistant S. aureus ATCC43300, with MIC values ranging from 1.5 μM to 18 μM, and shows no activity against E. faecalis ATCC19433 at tested concentrations[1].
RBWH15 (2.3-36 μM, 9-144 μM) permeabilizes the outer membranes of S. aureus ATCC25923 and P. aeruginosa PAO1 in a concentration-dependent manner[1].
RBWH15 (2.3-36 μM, 9-144 μM) disrupts the inner membranes of S. aureus ATCC25923 and P. aeruginosa PAO1 in a concentration-dependent manner, leading to increased PI uptake by membrane-compromised bacteria[1].
RBWH15 (2.3-36 μM, 9-144 μM; 90 min, 24 h) eradicates preformed biofilms of S. aureus ATCC25923 and P. aeruginosa PAO1 in a concentration-dependent manner[1].
RBWH15 (2.5-10 μM; 24-48 h) promotes migration of L929 mouse fibroblasts, accelerating in vitro wound closure over 48 h of incubation[1].
RBWH15 (30 min-24 h) exhibits moderate stability in human plasma, with ~35-44% of the peptide remaining intact after 24 h of incubation at 37 °C[1].
RBWH15 (30-60 μM; 1-3 h) is non-hemolytic against murine and human RBCs at concentrations up to 60 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:ESKAPE pathogens
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Concentration:0.375-200 μM
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Incubation Time:18-24 h
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Result:Potently inhibited the growth of various Gram-positive and Gram-negative ESKAPE pathogens-including Staphylococcus aureus ATCC 43300 (MRSA)-with MIC values ranging from 1.5 μM to 18 μM, while showing no activity against Enterococcus faecalis ATCC 19433 at the tested concentrations.
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Cell Line:L929 mouse fibroblasts
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Concentration:2.5 μM; 5 μM; 10 μM
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Incubation Time:24 h; 48 h
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Result:Promoted the migration of L929 mouse fibroblasts.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:unspecified strain (n=3 per group)[1]
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Dosage:0.3 mg/kg
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Administration:i.v.; single dose
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Result:Showed a non-significant body weight reduction of 2.97% 24 hours post-injection.
化学情報
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分子量 1583.10
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分子式 C79H143N19O14
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配列
IIKKLLGKLAKFVL-NH2
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シーケンスの短縮
Ile-Ile-Lys-Lys-Leu-Leu-Gly-Lys-Leu-Ala-Lys-Phe-Val-NH2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
RBWH15 関連分類
HY-P11898 関連分類
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- RBWH15
- RBWH 15
- RBWH-15
- Bacterial
- S. aureus ATCC25923
- L929 mouse fibroblasts
- A. baumannii AB5075
- HEK293 cells
- P. aeruginosa PAO1
- Gram-negative ESKAPE pathogens
- E. faecalis ATCC19433
- multidrug-resistant bacterial infections
- Gram-positive ESKAPE pathogens
- methicillin-resistant S. aureus ATCC43300
- Inhibitor
- inhibitor
- inhibit