Remikiren
Remikiren (Ro 42-5892) is an orally active and highly specific renin inhibitor. Remikiren specifically inhibits human reninand human plasma renin with IC50 values of 0.7 and 0.8 nM, respectively. Remikiren also reduces mean arterial blood pressure in sodium-depleted marmosets and squirrel monkeys. Remikiren can be used in study of hypertension.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 126222-34-2
- 分子式: C33H50N4O6S
- 分子量:630.84
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
IC50:0.7 nM (human pure renin), 0.8 nM (plasma renin of human)[1].
Remikiren (0-10 nM; 1-3 h) displays a considerable specificity to inhibit renin[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Human pure renin, plasma renin of human, marmoset, squirrel monkey
-
Concentration:0-10 nM
-
Incubation Time:1-3 h
-
Result:Inhibited human pure renin and plasma renin of human, marmoset, squirrel monkey with IC50 values of 0.7, 0.8, 1.0 and 1.7 nM, respectively.
Remikiren (3 mg/kg; p.o.; single) shows the duration of blood pressure decrease more than 24 h in sodium-depleted marmosets[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Marmosets and squirrel monkeys (sodium-depleted)[1].
-
Dosage:0.1, 0.3, 1, 3, 10 mg/kg
-
Administration:Oral administration; single.
-
Result:Decreased mean arterial pressure (MAP) by 20-25 mm Hg when at 0.1 mg/kg.
Reached the maximal decrease (30 mm Hg) of MAP with 1 mg/kg in marmosets.
Decreasesd 35 mm Hg blood pressure with 3-10 mg/kg in squirrel monkeys.
-
Animal Model:Marmosets (sodium-depleted)[1].
-
Dosage:3 mg/kg
-
Administration:Oral administration; single.
-
Result:Showed MAP fell by 30 mm Hg, which lasting more than 24 h.
化学情報
-
CAS 番号 126222-34-2
-
分子量 630.84
-
分子式 C33H50N4O6S
-
SMILES
CC(C)(C)S(C[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CN=CN2)C(N[C@H]([C@@H](O)[C@H](C3CC3)O)CC4CCCCC4)=O)=O)(=O)=O
-
別名
Ro 42-5892; Ro 42-5892/001
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Remikiren 関連分類
HY-A0184 関連分類
Powered by Bioz