SB-657510 (Standard)
SB-657510 (Standard) is the analytical standard of SB-657510 (HY-10656). This product is intended for research and analytical applications. SB-657510 is a selective urotensin II (UII) receptor (UT) antagonist. The Ki values are 61, 17, 30, 65 and 56 nM for human, monkey, cat, rat and mouse receptors, respectively. SB-657510 exerts anti-inflammatory effects by inhibiting UII-induced upregulation of inflammatory mediators such as adhesion molecules, cytokines, and tissue factor in human vascular endothelial cells.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 474960-44-6
- 分子式: C19H22BrClN2O5S
- 分子量:505.81
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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化学情報
- 純度とドキュメンテーション
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Help & FAQs
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HY-10656
SB-657510UII Receptor Antagonist -
HY-10664
SB-611812Urotensin Receptor Antagonist -
HY-108446
GSK 1562590 hydrochlorideUrotensin-II Receptor Antagonist -
HY-10657
SB-706375Urotensin II Receptor Antagonist -
HY-P1165
Urotensin II-related peptideUrotensin II Anague -
HY-10664R
SB-611812 (Standard)Urotensin Receptor Antagonist -
HY-10658
AC-7954Urotensin Receptor Agonist -
HY-P1166
UFP-803UT Antagonist -
HY-P1164
Urotensin II (114-124), humanUrotensin Receptor Agonist -
HY-10657R
SB-706375 (Standard)Reference Standard -
![[Orn5]-URP](https://file.medchemexpress.com/product_pic/hy-p1167.gif)
HY-P1167
[Orn5]-URPUT Antagonist -
HY-108055
Urantideurotensin-II Receptor Antagonist Peptide
Product Information
説明
アプリケーション
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
化学情報
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CAS 番号 474960-44-6
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分子量 505.81
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分子式 C19H22BrClN2O5S
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SMILES
ClC(C=C1)=C(O[C@H]2CN(C)CC2)C=C1NS(C3=CC(OC)=C(OC)C=C3Br)(=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Park SL, et al. Inhibitory Effect of an Urotensin II Receptor Antagonist on Proinflammatory Activation Inducedby Urotensin II in Human Vascular Endothelial Cells. Biomol Ther (Seoul). 2013 Jul 30;21(4):277-83. [Content Brief]
[2]. Behm DJ, et al. Palosuran inhibits binding to primate UT receptors in cell membranes but demonstrates differential activity in intact cells and vascular tissues. Br J Pharmacol. 2008 Oct;155(3):374-86. [Content Brief]
[3]. Watson AM, et al. Urotensin II receptor antagonism confers vasoprotective effects in diabetes associated atherosclerosis: studies in humans and in a mouse model of diabetes. Diabetologia. 2013 May;56(5):1155-65. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
SB-657510 (Standard) 関連分類
HY-10656R 関連分類
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