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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
467 Results for "
O2
" in MedChemExpress (MCE) Product Catalog:
Products (467)
467 Results for "O2" in MCE Product Catalog:
65
Target:
研究分野:
UK-5099 (PF-1005023) is a potent inhibitor of the mitochondrial pyruvate carrier (MPC). UK-5099 (PF-1005023) inhibits pyruvate-dependent O2 consumption with an IC50 of 50 nM.
20
Category:
Human Gut Microbiota Metabolites 天然物 Microorganisms Anti-aging Metabolic Disease Endogenous metabolite Disease Research Fields
Target:
20
Category:
天然物 Animals Metabolic Disease Plants Other Families Extract Endogenous metabolite Disease Research Fields
Target:
20
Category:
天然物 Neurological Disease Orchidaceae Extract Gastrodia elata Bl. Anti-aging Phenols Plants Disease Research Fields Inflammation/Immunology
Target:
15
15 Cited Publications
別名: Luteolin 7-glucoside; Luteolin 7-O-β-D-glucoside
Category:
Flavones Plants Infection Flavonoids Umbelliferae Extract Centaurea ornata Phenols Polyphenols Compositae Extract Disease Research Fields Cirsium vulgare(Savi) Ten.
13
13 Cited Publications
Target:
研究分野:
CORM-401 is an oxidant-sensitive CO-releasing molecule. CORM-401 induces NO increase in the regulation of endothelial calcium signalling. CORM-401 reduces TNF-α/CHX and H2O2-induced ROS production. CORM-401 uncouples mitochondrial respiration and inhibits glycolysis [2] .
8
Target:
研究分野:
Glucose oxidase is used in the food and beverage industry as a preservative and stabilizer and is commonly derived from the fungus Aspergillus niger. Glucose oxidase can react with intracellular glucose and oxygen (O2) to produce hydrogen peroxide (H2O2) and gluconic acid, which can cut off the nutrition source of cancer cells and consequently inhibit their proliferation [2] .
8
Evofosfamide (TH-302) is a hypoxia-activated proagent with IC50 of 10 μM and 1000 μM in hypoxia (N2) and normoxia (21% O2), respectively.
8
7
7 Cited Publications
別名: Diethylnorspermine tetrahydrochloride; DENSPM tetrahydrochloride; BENSPM tetrahydrochloride
N1, N11-Diethylnorspermine tetrahydrochloride (DENSPM tetrahydrochloride) is a potent anticancer agent. N1,N11-Diethylnorspermine tetrahydrochloride activates polyamine catabolism and downregulates mTOR protein. N1,N11-Diethylnorspermine tetrahydrochloride induces the release of cytochrome c from mitochondria, resulting in activation of caspase 3. N1,N11-Diethylnorspermine tetrahydrochloride kills glioblastoma multiforme (GBM) through induction of SSAT (spermidine/spermine N1-acetyltransferase) coupled with H2O2 production [2] .
6
Category:
Flavonoids Monophenols Neurological Disease Flavones Phenols Plants Other Families Extract Disease Research Fields Inflammation/Immunology
Target:
6
Target:
研究分野:
Catalase, Aspergillus niger is a key enzyme in the metabolism of H2O2 and reactive oxygen species (ROS), and its expression and localization is markedly altered in tumors . Free oxygen radical scavenger.
6
6 Cited Publications
製品番号: HY-D1157
CAS 番号: 2245230-79-7
5
4
Category:
Triterpenes Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow Terpenoids Other Diseases Plants Disease Research Fields Araliaceae Extract
4
Target:
研究分野:
2,7-Dichlorodihydrofluorescein (DCFH2) is a non-fluorescent reactive oxygen species (ROS) probe with an excitation wavelength of 485-500 nm and an emission wavelength of 515-530 nm. 2,7-Dichlorodihydrofluorescein is first hydrolyzed by intracellular esterases and then oxidized by ROS to generate non-biomembrane-permeable, highly fluorescent 2,7-dichlorofluorescein (DCF). The fluorescence intensity of DCF is positively correlated with the ROS concentration. 2,7-Dichlorodihydrofluorescein can undergo oxidation reactions with a variety of ROS (such as ·OH, H2O2, ONOO -, etc.) and is used to quantitatively detect the level of oxidative stress inside and outside cells. It is suitable for oxidative stress analysis in in vitro cell models and in vivo targeted delivery (such as liver-targeted liposomes) [2].
3
Evolocumab (AMG 145) is a human monoclonal antibody that inhibits PCSK9. Evolocumab is used in the study of hypercholesterolemia and atherosclerotic cardiovascular disease. Evolocumab binds to circulating PCSK9 protein and inhibits its binding to LDLR. Evolocumab has antioxidant and cytoprotective activities against H2O2-induced oxidative damage to endothelial cells. Evolocumab may also negatively regulate activation of the TLR-4/NF-κB signaling pathway to prevent inflammation [2] .
3
2
2 Cited Publications
製品番号: HY-D1156A
2
2 Cited Publications
製品番号: HY-P2733D
Target:
研究分野:
Glycerol 3-phosphate Oxidase, Streptococcus thermophilus (EC 1.1.3.21), is an oxidoreductase that acts on the CH-OH group in donor molecules and uses oxygen as an acceptor. Glycerol 3-phosphate Oxidase participates in glycerophospholipid metabolism and utilizes a cofactor, FAD. The two substrates of Glycerol 3-phosphate Oxidase are sn-glycerol-3-phosphate and O2, while its two products are glycerophosphate and H2O2.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
