SN 6 (Standard)
SN 6 (Standard) is the analytical standard of SN 6 (HY-107658). This product is intended for research and analytical applications. SN 6 is a selective Na+/Ca2+ exchanger (NCX) inhibitor, and inhibits 45Ca2+ uptake by NCX1, NCX2, and NCX3, with IC50s of 2.9, 16, and 8.6 μM, respectively.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 415697-08-4
- 分子式: C20H22N2O5S
- 分子量:402.46
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-107658
SN 6Na+/Ca2+ Exchanger Inhibitor -
HY-15754
CGP37157Na+/Ca2+ Exchanger Inhibitor -
HY-15415
KB-R7943 mesylateNCXrev Inhibitor -
HY-15515
SEA0400Na+/Ca2+ Exchanger Inhibitor -
HY-B1546A
Benzamil hydrochlorideENaC Blocker -
HY-123785
ORM-10962NCX Inhibitor -
HY-15515R
SEA0400 (Standard)Na+/Ca2+ Exchanger Inhibitor -
HY-128678
ORM-10103Na+/Ca2+ Exchanger Inhibitor -
HY-107659
YM-244769 hydrochlorideNCX Inhibitor -
HY-136182
YM-244769 dihydrochlorideNCX Inhibitor -
HY-100298
CaldaretCa2+ Handling Modulator -
HY-136182A
YM-244769NCX Inhibitor
生物活性
製品説明
IC50 & Target
IC50：2.9 μM (NCX1), 16 μM (NCX2), 8.6 μM (NCX3)[1]
化学情報
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CAS 番号 415697-08-4
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分子量 402.46
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分子式 C20H22N2O5S
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SMILES
CCOC(C(CS1)NC1CC2=CC=C(OCC3=CC=C([N+]([O-])=O)C=C3)C=C2)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
プロトコル
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Ca2+ Staining Technique
Ca2+ staining is an experimental technique that utilizes specific fluorescent probes (such as Fluo-4 AM, Fura-2, etc.) to qualitatively or quantitatively detect dynamic changes in intracellular Ca2+ concentrations; this is achieved by monitoring the changes in fluorescent signals generated when these probes bind to free intracellular calcium ions. The underlying principle relies primarily on the presence of chelating groups within the probe's molecular structure that possess high affinity for calcium ions.
純度とドキュメンテーション
参考文献
[1]. Iwamoto T, et al. The exchanger inhibitory peptide region-dependent inhibition of Na+/Ca2+ exchange by SN-6 [2-[4-(4-nitrobenzyloxy)benzyl]thiazolidine-4-carboxylic acid ethyl ester], a novel benzyloxyphenyl derivative. Mol Pharmacol. 2004 Jul;66(1):45-55. [Content Brief]
[2]. Niu CF, et al. Electrophysiological effects of SN-6, a novel Na+/Ca2+ exchange inhibitor on membrane currents in guinea pig ventricular myocytes. Ann N Y Acad Sci. 2007 Mar;1099:534-9. [Content Brief]
[3]. Kita S, et al. Inhibitory mechanism of SN-6, a novel benzyloxyphenyl Na+/Ca2+ exchange inhibitor. Ann N Y Acad Sci. 2007 Mar;1099:529-33. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
SN 6 (Standard) 関連分類
HY-107658R 関連分類
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