Sorbitan trioleate
Based on 1 Customer Validation
Sorbitan trioleate (Span 85) is an orally active non-ionic surface active agent. Sorbitan trioleate can be used as an excipient, such as surfactant, emulsifier, lubricant, wetting agent, dispersant, thickener, defoamer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 26266-58-0
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保管条件:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Pharmaceutical excipients, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2][3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rats (5-week-old)[2]
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Dosage:12.5; 50.0; 200.0 mg/kg
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Administration:i.v.; daily; 35 days
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Result:Showed no abnormalities in general symptoms, body weight gain, or food/water consumption compared to controls at all doses.
Observed only a significant decrease in Na and Cl levels in males at 12.5 mg/kg.
Found any statistically significant changes in hematological, serum biochemical, or organ weight parameters fell within normal ranges at 12.5 mg/kg and 50.0 mg/kg.
Showed no meaningful gross or histological tissue changes beyond minor, non-toxic effects at 12.5 mg/kg and 50.0 mg/kg.
Induced significant decreases in red blood cell count, hemoglobin, and hematocrit, alongside significant increases in prothrombin time and reticulocyte count, indicating mild anemia at 200.0 mg/kg.
Caused significant increase in total cholesterol; significant decreases in male alkaline phosphatase, blood urea nitrogen, albumin, A/G ratio, sodium, chloride, and creatinine; significant decreases in female glutamic-oxaloacetic transaminase, glutamic-pyruvic transaminase, albumin, A/G ratio, sodium, chloride, and creatinine at 200.0 mg/kg.
化学情報
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CAS 番号 26266-58-0
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性状 Liquid (Density: 0.94 g/cm3)
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Color Colorless to light yellow
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SMILES
CCCCCCCC/C=C\CCCCCCCC(OC[C@@H](O)[C@@H]1[C@H](OC(CCCCCCC/C=C\CCCCCCCC)=O)[C@@H](OC(CCCCCCC/C=C\CCCCCCCC)=O)CO1)=O
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別名
Span 85
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 200 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
純度とドキュメンテーション
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データシート (266 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Sonwai S, et al. Crystallization kinetics of cocoa butter in the presence of sorbitan esters. Food Chem. 2017;214:497-506. [Content Brief]
[2]. Yamamoto H, et al. Study on subacute toxicity of intravenous sorbitan trioleate (STO) in Wistar rats. J Toxicol Sci. 1983;8(4):301-310. [Content Brief]
[3]. Lanigan RS, et al. Final report on the safety assessment of sorbitan caprylate, sorbitan cocoate, sorbitan diisostearate, sorbitan dioleate, sorbitan distearate, sorbitan isostearate, sorbitan olivate, sorbitan sesquiisostearate, sorbitan sesquistearate, and sorbitan triisostearate. Int J Toxicol. 2002;21 Suppl 1:93-112. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
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