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United States

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製品番号: HY-189941

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SP-835G

SP-835G is a potent Dengue Virus inhibitor with an EC₅₀ of 0.1 μM against DENV2. SP-835G, as a prodrug, is reduced by mitochondrial MARC enzymes to the active metabolite SP-835A, which binds to the allosteric site of NS2B-NS3 protease and blocks both cis and trans cleavage of the protease by restricting the dynamic changes of the helicase subdomain. SP-835G inhibits Dengue virus replication in infected cells with very low cytotoxicity. SP-835G can be used for research on dengue fever.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₂₇H₂₃BrN₈O₃
分子量:587.43

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

SP-835G 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-7	EC₅₀	0.1 μM	Antiviral activity against human HuH7 cells infected with EDEN2 (DENV2) at MOI 0.3 one-hour post infection, measured as EC50 average of two independent experiments. Antiviral activity against human HuH7 cells infected with EDEN2 (DENV2) at MOI 0.3 one-hour post infection, measured as EC50 average of two independent experiments.	slct.74553
Huh-7	CC₅₀	> 100 μM	Cytotoxicity against human HuH7 cells assessed up to 100 μM with CC₅₀ >100 μM. Cytotoxicity against human HuH7 cells assessed up to 100 μM with CC₅₀ >100 μM.	slct.74553

体外実験

Viral Infection

SP-835G (48 h) significantly inhibits viral replication in DENV2 (EDEN2)-infected HuH-7 cells, with an EC₅₀ of 0.1 μM and very low cytotoxicity (CC₅₀ > 100 μM)^[1].
SP-835G (100 μM) achieves up to 97% viral clearance in BHK-21 cells infected with DENV2 (EDEN2)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

化学情報

分子量 587.43
分子式 C₂₇H₂₃BrN₈O₃
SMILES

N/C(C1=CC(C2=NC(N(CC3=CC=C(Br)C=C3)C=N4)=C4C(OCC5=CC=CC(/C(N)=N/O)=C5)=N2)=CC=C1)=N\O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Kiousis D, et al. Design and synthesis of a potent, cell active purine-based amidoxime against the dengue virus. ChemistrySelect. 2026.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量分子量

希釈計算機

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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