STA-9584
STA-9584 is a potent vascular disrupting agent (VDA) that targets tubulin. STA-9584 exhibits potent antitumor activity in mouse xenograft model by selectively targeting microvasculature at both the center and periphery of tumors. STA-9584 can be used for research in prostate and breast cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 906481-23-0
- 分子式: C28H30ClN3O6
- 分子量:540.01
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female BALB/c mice (7-12 weeks old) subcutaneously implanted with EMT6 cells[1]
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Dosage:4.5 mg/kg
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Administration:i.v., weekly for 2 weeks
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Result:Completely blocked blood flow in highly perfused tumor subregions within 4 h of drug administration.
Completely arrested tumor growth over this period with a single dose for 24 h.
Exhibited far more extensive cellular destruction throughout the entire tumor, including areas of fibrosis and dramatically reduced viable rim or surviving tumor zones.
Resulted in no detectable viable rim tissue in many tumor sections.
Increased microvasculature destruction and consequent apoptosis in peripheral regions of tumors.
Induced widespread disruption of tumor microvessels, characterized by decreased, patchy CD31 expression, loss of integrity, and thrombosis.
Decreased CD31 endothelial cells in the viable rim by 77%.
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Animal Model:Female BALB/c nude mice (7-12 weeks old) subcutaneously implanted with PC-3 cells[1]
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Dosage:4.5 mg/kg
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Administration:i.v., weekly for 3 weeks
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Result:Induced significantly tumor regression (40%) compared with the control group.
Was well tolerated with minimal loss of body weight during the course of treatment.
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Animal Model:Female CB-17/ Icr-Prkdcscid (SCID) mice (7-12 weeks old) subcutaneously implanted with MDA-MB-231 cells[1]
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Dosage:4.5 mg/kg
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Administration:i.v., weekly for 3 weeks
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Result:Resulted in 60% tumor regression.
化学情報
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CAS 番号 906481-23-0
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分子量 540.01
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分子式 C28H30ClN3O6
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SMILES
O=C(NC1=CC(C2=C(C3=CC(OC)=C(OC)C(OC)=C3)ON=C2)=CC=C1OC)[C@@H](N)CC4=CC=CC=C4.Cl
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
STA-9584 関連分類
HY-111170 関連分類
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