TQ05310
TQ05310 is an orally available inhibitor of IDH2 mutants, targeting both IDH2-R140Q (IC50=136.9 nM) and IDH2-R172K (IC50=37.9 nM) mutants. TQ05310 inhibits the production of 2-hydroxyglutarate (2-HG) and induces differentiation of cells expressing IDH2-R140Q and IDH2-R172K by inhibiting the enzymatic activity of mutant IDH2. TQ05310 can be used for the study of acute myeloid leukemia.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2071196-10-4
- 分子式: C19H17F6N7O
- 分子量:473.37
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
IDH2-R140Q 136.9 nM (IC50) |
IDH2‐R172K 37.9 nM (IC50) |
化学情報
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CAS 番号 2071196-10-4
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分子量 473.37
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分子式 C19H17F6N7O
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SMILES
FC(F)(F)C1=CC=CC(C2=NC(NC3=CC=NC(C(F)(F)F)=C3)=NC(NOC(C)(C)C)=N2)=N1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
TQ05310 関連分類
HY-164542 関連分類
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