VP3.15
Based on 3 publication(s) in Google Scholar
VP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS).
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1281681-54-6
- 分子式: C20H22N4OS
- 分子量:366.48
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 VP3.15
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生物活性
IC50: 1.59 μM (PDE7), 0.88 μM (GSK-3)[1]
化学情報
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CAS 番号 1281681-54-6
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分子量 366.48
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分子式 C20H22N4OS
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SMILES
N1(CC/N=C2N=C(C3=CC=CC=C3)N(C4=CC=CC=C4)S/2)CCOCC1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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J Biol Chem
REDD1-dependent GSK3β signaling in podocytes promotes canonical NF-κB activation in diabetic nephropathy. [Abstract]2025 Jan 27:108244. PMID: 39880090 -
J Biol Chem
REDD1-dependent GSK3β dephosphorylation promotes NF-κB activation and macrophage infiltration in the retina of diabetic mice. [Abstract]2023 Aug;299(8):104991. PMID: 37392853 -
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
VP3.15 関連分類
HY-128879 関連分類
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