VTX-1218
Based on 1 Customer Validation
VTX-1218 is a VSIG4 inhibitor with human Kd 7.4 nM. VTX-1218 blocks VSIG4 activity, relieves VSIG4-mediated macrophage suppression, repolarizes tumor-associated macrophages and induces T cell activation. VTX-1218 upregulates cytokines and chemokines linked to immune cell recruitment. VTX-1218 can be used for the research of multiple cancer types.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.9%
- 分子量:145.32 kDa
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
Human IgG1 kappa
Human
VSIG4
VTX-1218 binds recombinant human, cynomolgus monkey, and rhesus monkey VSIG4 extracellular domain proteins with high affinity, exhibiting Kd values of 7.4 nM, 8.1 nM, and 9.6 nM, respectively[1].
VTX-1218 dose-dependently blocks the interaction of human VSIG4 with its complement ligands C3b and iC3b[1].
VTX-1218 repolarizes tumor-associated macrophages to proinflammatory phenotypes and promotes T cell-mediated tumor killing in primary cell in vitro assays and fresh human tumor cultures[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Q9Y279-1
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
ELISA, FACS, Functional assay
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Immobilized VSIG4 Protein, Human can bind VTX-1218. The EC50 for this effect is 64.7 ng/mL.
化学情報
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性状 Liquid
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分子量 145.32 kDa
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Color Colorless to light yellow
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SMILES
[3H][V][X1218]
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輸送条件
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
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データシート (257 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
参考文献
[1]. Sazinsky S, et al. Antibodies Targeting Human or Mouse VSIG4 Repolarize Tumor-Associated Macrophages Providing the Potential of Potent and Specific Clinical Anti-Tumor Response Induced across Multiple Cancer Types. Int J Mol Sci. 2024;25(11):6160. Published 2024 Jun 3. [Content Brief]
[2]. Miyamoto T, et al. Intraperitoneal metastasis of ovarian cancer: new insights on resident macrophages in the peritoneal cavity. Front Immunol. 2023;14:1104694. Published 2023 Apr 25. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)