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VSIG4 - V-set and immunoglobulin domain containing 4 Gene

Also Known as CRIg; Z39IG

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11326

About VSIG4

Cytogenetic location: Xq12 Genomic coordinates (GRCh38): X:66,021,738-66,040,080 (from NCBI)

This gene has 5 transcripts (splice variants) and 121 orthologues. Broad expression in placenta (RPKM 50.4), lung (RPKM 39.9) and 19 other tissues.

Summary

This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the Complement Component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

VSIG4 Products (5)

mRNA	Protein	Name
NM_001100431.2	NP_001093901.1	V-set and immunoglobulin domain-containing protein 4 isoform 2 precursor
NM_001184830.2	NP_001171759.1	V-set and immunoglobulin domain-containing protein 4 isoform 4 precursor
NM_001184831.2	NP_001171760.1	V-set and immunoglobulin domain-containing protein 4 isoform 3 precursor
NM_001257403.2	NP_001244332.1	V-set and immunoglobulin domain-containing protein 4 isoform 5 precursor
NM_007268.3	NP_009199.1	V-set and immunoglobulin domain-containing protein 4 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables complement component C3b binding	IPI IPI: Inferred from physical interaction	17051150	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16530040	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of complement activation, alternative pathway	IPI IPI: Inferred from physical interaction	17051150	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of protein-containing complex	IPI IPI: Inferred from physical interaction	17051150	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VSIG4 Protein Structure

V-set

Ig_3

0
100
200
300
399 a.a.

Protein Preferred Names	Protein Names
V-set and immunoglobulin domain-containing protein 4	Ig superfamily protein

VSIG4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	VSIG4	Q9Y279	FATE1	Homo sapiens	Q969F0	Y2H Array	32296183
Intra	VSIG4	Q9Y279	FATE1	Homo sapiens	Q969F0	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant VSIG4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71423	VSIG4 Protein, Human (HEK293, Fc)	Q9Y279-1 (R20-V284)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P71424	VSIG4 Protein, Human (HEK293, His)	Q9Y279-1 (R20-P283)	≥ 95%, as determined by reducing SDS-PAGE.

VSIG4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P87145	VSIG4 Antibody (YA6838)	WB, IHC-P	Human

Related Diseases

Diseases	Alias
Hemolytic Uremic Syndrome, Atypical 1	Atypical Hemolytic-Uremic Syndrome Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1 Atypical Hemolytic Uremic Syndrome Hemolytic Uremic Syndrome, Atypical, Susceptibility To Ahus AHUS1 Hemolytic-Uremic Syndrome Ahus 1 Ahus, Susceptibility To, 1 Hemolytic Uremic Syndrome, Atypical Non-Shiga-Like Toxin-Associated Hus Non-Stx-Hus Nonenteropathic Hus Atypical Hus Shiga Toxin-Associated Hemolytic Uremic Syndrome D+ Hus Ehec-Hus Hemolytic Uremic Syndrome Associated With Shiga Toxin-Producing Escherichia Coli Hemolytic Uremic Syndrome With Diarrhea Stec-Hus Shiga-Like Toxin-Associated Hus Stx-Hus Typical Hus Typical Hemolytic Uremic Syndrome Atypical Hemolytic Uremic Syndrome With Anti-Factor H Antibodies Atypical Hus With Anti-Factor H Antibodies Ahus With Anti-Factor H Antibodies Ahus With Neutralizing Autoantibodies Against Factor H Hemolytic Uremic Syndrome Atypical 1 Atypical Hemolytic Uremic Syndrome With H Factor Anomaly D Hus Hemolytic-Uremic Syndrome Without Diarrhea Hemolytic-Uremic Syndrome, Atypical, Type 1 Hemolytic Uremic Syndrome, Typical
Chromophobe Renal Cell Carcinoma	Chromophobe Adenocarcinoma Chromophobe Carcinoma Of Kidney Kidney Chromophobe Renal Cell Carcinoma, Chromophobe Cell Crcc Chrcc Chromophobe Renal Cell Adenocarcinoma Chromophobe Renal Carcinoma Chromophobe Carcinoma
Diamond-Blackfan Anemia 1	Aase Syndrome DBA1 Erythrogenesis Imperfecta Aase-Smith Syndrome Ii Dba Blackfan-Diamond Syndrome Bds Anemia, Congenital Hypoplastic, Of Blackfan And Diamond Anemia, Congenital Erythroid Hypoplastic Red Cell Aplasia, Pure, Hereditary Aregenerative Anemia, Chronic Congenital Rps19-Related Diamond-Blackfan Anemia Chronic Congenital Aregenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Pure Hereditary Red Cell Aplasia Anemia, Diamond-Blackfan, Type 1 Anemia, Diamond-Blackfan Aase Smith Syndrome 2 Familial Hypoplastic Anaemia With Malformations Constitutional Pure Red Cell Aplasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive MoleculesInhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P991217	EU-103	Inhibitor	99.0%	Phase 1

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15709	VSIG4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17561	Vsig4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24019	Vsig4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Bioactive MoleculesInhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991181	VTX-1218	Inhibitor	99.9%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	VSIG4	RGD	RGD:1564659
Macaca mulatta	VSIG4	VGNC	VGNC:79062
Mus musculus	VSIG4	MGD	MGI:2679720
Bos taurus	VSIG4	VGNC	VGNC:36840
Canis familiaris	VSIG4	VGNC	VGNC:48308
Felis catus	VSIG4	VGNC	VGNC:66978
Macaca fascicularis	VSIG4	NCBI	NCBI:102144784
Others	VSIG4	NCBI