2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. VTX-1218

VTX-1218 is a VSIG4 inhibitor with human Kd 7.4 nM. VTX-1218 blocks VSIG4 activity, relieves VSIG4-mediated macrophage suppression, repolarizes tumor-associated macrophages and induces T cell activation. VTX-1218 upregulates cytokines and chemokines linked to immune cell recruitment. VTX-1218 can be used for the research of multiple cancer types.

For research use only. We do not sell to patients.

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Based on 1 publication(s) in Google Scholar

VTX-1218 Related Antibodies

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Description

VTX-1218 is a VSIG4 inhibitor with human Kd 7.4 nM. VTX-1218 blocks VSIG4 activity, relieves VSIG4-mediated macrophage suppression, repolarizes tumor-associated macrophages and induces T cell activation. VTX-1218 upregulates cytokines and chemokines linked to immune cell recruitment. VTX-1218 can be used for the research of multiple cancer types[1][2].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target

VSIG4
In Vitro

VTX-1218 binds recombinant human, cynomolgus monkey, and rhesus monkey VSIG4 extracellular domain proteins with high affinity, exhibiting Kd values of 7.4 nM, 8.1 nM, and 9.6 nM, respectively[1].
VTX-1218 dose-dependently blocks the interaction of human VSIG4 with its complement ligands C3b and iC3b[1].
VTX-1218 repolarizes tumor-associated macrophages to proinflammatory phenotypes and promotes T cell-mediated tumor killing in primary cell in vitro assays and fresh human tumor cultures[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VTX-1218 Related Antibodies
In Vivo

VTX-1218 exhibits synergistic anti-cancer activity with immune checkpoint therapy in syngeneic mouse models by repolarizing tumor-associated macrophages to proinflammatory phenotypes and enhancing T cell-mediated tumor killing.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Gene ID

11326  [NCBI]

Accession

Q9Y279-1
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

145.32 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[3H][V][X1218]
Shipping

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
  • Immobilized VSIG4 Protein, Human can bind VTX-1218. The EC50 for this effect is 64.7 ng/mL.
Purity & Documentation
References
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VTX-1218 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VTX-1218VTX1218VTX 1218Transmembrane GlycoproteinT celliC3btumor-associated macrophagesCD8+ T cellimmune checkpoint therapymacrophageC3bVSIG4syngeneic mouse modelshuman monocyte-derived M2c macrophagesInhibitorinhibitorinhibit

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