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製品番号: HY-186145

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WMK-1

WMK-1 is a 1,2,4,5-tetraoxane derivative and ferroptosis inducer, with significantly higher cytotoxicity against cancer cells than non-cancerous cells. WMK-1 triggers ferroptosis in cancer cells and cancer stem cells. WMK-1 can be used for the research of cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2814563-83-0
分子式: C₃₅H₅₁IN₂O₆
分子量:722.69

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

WMK-1 構造式

CAS 番号: 2814563-83-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

WMK-1 (compound 48) (48 h) potently inhibits viability of MDA-MB-231, Hela, T47D, Jurkat, HCT116, and HL-60 cancer cells with IC₅₀ values ranging from 1.0 μM to 6.3 μM^[1].
WMK-1 (48 h) potently inhibits viability of HeyA8 ovarian cancer cells (IC₅₀ = 2.3 μM) and HeyA8sp ovarian cancer stem cell spheres (IC₅₀ = 1.2 μM)^[1].
WMK-1 (24 h) induces ferroptosis in HeyA8 ovarian cancer cells, HeyA8 ovarian cancer stem cells, and HeyA8 ovarian cancer stem cell spheres^[1].
WMK-1 (5 μM; 6 h) increases lipid reactive oxygen species levels in MDA-MB-231 triple negative breast cancer cells^[1].
WMK-1 (5 μM) induced cell death in MDA-MB-231 triple-negative breast cancer cells at indicated concentrations within 24 h, and this effect was significantly reversed by 30 μM liproxstatin-1 (HY-12726) pretreatment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

WMK-1 (compound 48) (5-10 mg/kg, i.p.) reduced tumor burden in both ovarian cancer and triple-negative breast cancer xenograft models in nude mice, with no observable systemic or organ-related toxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Nude mice (female)^[1]
Dosage:

5 mg/kg; 10 mg/kg
Administration:

i.p.
Result:

Reduced ovarian cancer xenograft tumor size.
Caused no abnormal behavior or weight loss in treated animals during the entire study period.

化学情報

CAS 番号 2814563-83-0
分子量 722.69
分子式 C₃₅H₅₁IN₂O₆
SMILES

CC(C)(C)C1CCC2(OOC3(CCC(OC(NCCC[N+](CC4=CC=CC=C4)(C)CC5=CC=CC=C5)=O)CC3)OO2)CC1.[I-]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Dan Yang, et al. Targeted delivery of 1, 2, 4, 5-tetraoxane compounds and their uses, WO, WO2022161490A1, 2022-08-04.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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