HSPA14 - heat shock protein family A (Hsp70) member 14 Gene

Also Known as HSP70-4; HSP70L1; MSANTD7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51182

About HSPA14

Cytogenetic location: 10p13 Genomic coordinates (GRCh38): 10:14,838,306-14,871,741 (from NCBI)

This gene has 3 transcripts (splice variants), 204 orthologues and 13 paralogues. Ubiquitous expression in testis (RPKM 8.1), bone marrow (RPKM 6.5) and 25 other tissues.

Summary

Predicted to enable several functions, including ATP binding activity; misfolded protein binding activity; and unfolded protein binding activity. Predicted to be involved in several processes, including cellular response to unfolded protein; chaperone cofactor-dependent protein refolding; and protein refolding. Located in cytosol. Colocalizes with ribosome. [provided by Alliance of Genome Resources, Apr 2022]

HSPA14 Products (1)

mRNA Protein Name
NM_016299.4 NP_057383.2 heat shock 70 kDa protein 14

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16002468 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
16002468 GOA
colocalizes with ribosome IDA
IDA: Inferred from direct assay
16002468 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HSPA14 Protein Structure

HSP70

HSP70: Hsp70 protein (3 - 506)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 509 a.a.
Protein Preferred Names Protein Names

heat shock 70 kDa protein 14

  • HSP70-like protein 1

HSPA14 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HSPA14 Q0VDF9 DNAJC2 Homo sapiens Q99543
Anti Tag CoIP
35271311
Cross: Cross-species interaction Intra: Intraspecies interaction

HSPA14 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83258 HspA14 Antibody (YA3003) WB, ICC/IF, IP Human, Mouse
HY-P83258A HspA14 Antibody (YA3003)(PBS only) WB, ICC/IF, IP Human, Mouse

Related Diseases

Diseases Alias
Autoimmune Atherosclerosis
Tetralogy Of Fallot

  • TOF

  • Fallot Tetralogy

  • Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle

  • Tetrad Of Fallot

  • Fallot Tetrad

  • Fallot Disease

  • Fallot Complex

  • Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy

  • Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle

  • Interventricular Septal Defect, In Tetralogy Of Fallot

  • Ventricular Septal Defect With Obstructed Right Ventricular Outflow

  • Tof - [Tetralogy Of Fallot]

  • Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]

  • Pulmonary Atresia, Ventricular Septal Defect And Mapcas

  • Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06423 HSPA14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus HSPA14 MGD MGI:1354164
Felis catus HSPA14 VGNC VGNC:84034
Rattus norvegicus HSPA14 RGD RGD:1303296
Macaca mulatta HSPA14 VGNC VGNC:106060
Canis familiaris HSPA14 VGNC VGNC:52137
Others HSPA14 NCBI