2. Gene
  3. DNAJC2 - DnaJ heat shock protein family (Hsp40) member C2 Gene

DNAJC2 - DnaJ heat shock protein family (Hsp40) member C2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as ZRF1; ZUO1; MPP11; MPHOSPH11

Gene ID: 27000 | Gene type: protein coding

About DNAJC2

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:103,312,289-103,344,767 (from NCBI)

This gene has 11 transcripts (splice variants), 231 orthologues and 20 paralogues. Ubiquitous expression in bone marrow (RPKM 19.0), testis (RPKM 17.8) and 25 other tissues.

Summary

This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described. [provided by RefSeq, Jul 2008]

DNAJC2 Products(4)

mRNA Protein Name
NM_001129887.3 NP_001123359.1 dnaJ homolog subfamily C member 2 isoform 2
NM_001362667.2 NP_001349596.1 dnaJ homolog subfamily C member 2 isoform 3
NM_001362668.2 NP_001349597.1 dnaJ homolog subfamily C member 2 isoform 4
NM_014377.3 NP_055192.1 dnaJ homolog subfamily C member 2 isoform 1

DNAJC2 Protein Structure

DnaJ

DnaJ: DnaJ domain (88 - 157)

Myb_DNA-binding

Myb_DNA-binding: Myb-like DNA-binding domain (452 - 500)

Myb_DNA-binding

Myb_DNA-binding: Myb-like DNA-binding domain (553 - 598)

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  • 621 a.a.
Protein Preferred Names Protein Names

dnaJ homolog subfamily C member 2

DnaJ (Hsp40) homolog, subfamily C, member 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03881 DNAJC2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus DNAJC2 VGNC VGNC:78443
Bos taurus DNAJC2 VGNC VGNC:53636
Rattus norvegicus DNAJC2 RGD RGD:620524
Mus musculus DNAJC2 MGD MGI:99470
Canis familiaris DNAJC2 VGNC VGNC:51863
Macaca mulatta DNAJC2 VGNC VGNC:81305
Others DNAJC2 NCBI