CLK4
CLK4 is the most divergent of the CDC-like kinases and remains the least understood. It preserves the family signature of an RS-rich N-terminal segment followed by a dual-specificity catalytic domain capable of activation-loop tyrosine autophosphorylation and of serine phosphorylation of SR-type splicing factors. Expression is comparatively low and tissue-restricted, and its nuclear localization overlaps the speckle compartment used by CLK1, CLK2, and CLK3. Functional studies based on overexpression and inhibition place CLK4 in the control of pre-mRNA splicing and cell proliferation, although isoform-specific substrates are still being defined. Recombinant CLK4 completes CLK-family panels for splicing research and kinase-inhibitor selectivity assessment.
-
CLK4 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
