BAY 11-7085
Based on 51 publication(s) in Google Scholar
BAY 11-7085 (BAY 11-7083) is an inhibitor of NF-κB activation and phosphorylation of IκBα; it stabilizes IκBα with an IC50 of 10 μM.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.96%
- CAS No.: 196309-76-9
- 화학식: C13H15NO2S
- 분자량:249.33
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- Protocol
- 순도&문서
- References
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Immunology/Inflammation Compound Library
HY-L007
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NF-κB Signaling Compound Library
HY-L014
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Stem Cell Signaling Compound Library
HY-L017
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Anti-Cancer Compound Library
HY-L025
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Anti-Aging Compound Library
HY-L034
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Antioxidant Compound Library
HY-L037
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Differentiation Inducing Compound Library
HY-L038
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Oxygen Sensing Compound Library
HY-L045
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Ferroptosis Compound Library
HY-L051
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Pyroptosis Compound Library
HY-L059
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Anti-Breast Cancer Compound Library
HY-L074
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Anti-Pancreatic Cancer Compound Library
HY-L077
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Anti-Blood Cancer Compound Library
HY-L079
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Anti-Cancer Metabolism Compound Library
HY-L083
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Anti-Obesity Compound Library
HY-L087
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Transcription Factor-Targeted Library
HY-L090
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Anti-Liver Cancer Compound Library
HY-L101
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Antidepressant Compound Library
HY-L108
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Anti-Prostate Cancer Compound Library
HY-L124
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Cancer Stem Cells Compound Library
HY-L135
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Pain-Related Compound Library
HY-L139
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Cysteine Targeted Covalent Library
HY-L153
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Cysteine Targeted Covalent Fragment Library
HY-L154
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Cell Death Library
HY-L162
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Anti-Hematopathy Compound Library
HY-L171
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Anti-Ovarian Cancer Compound Library
HY-L173
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Multi-Target Compound Library
HY-L176
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Radioprotector Library
HY-L178
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Anti-Fibrosis Compound Library
HY-L185
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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Cell Proliferation Compound Library
HY-L201
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High-Throughput Bioactive Compound Library
HY-L205
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Lactylation Compound Library
HY-L249
Publications Citing Use of MedChemExpress (MCE) BAY 11-7085
More- Signal Transduct Target Ther. 2025 Dec 15;10(1):406. [Abstract]
- Cancer Cell. 2024 Dec 9;42(12):2015-2031.e11. [Abstract]
- Cell Host Microbe. 2025 Jun 11;33(6):915-931.e9. [Abstract]
- Hepatology. 2020 May;71(5):1660-1677. [Abstract]
- Carbohydr Polym. 2024 Dec 15:346:122586. [Abstract]
- Cell Death Dis. 2020 Nov 15;11(11):982. [Abstract]
- Cell Commun Signal. 2025 Nov 13;23(1):496. [Abstract]
- Phytomedicine. 2024 Jan:123:154928. [Abstract]
- Phytomedicine. 2023 Apr:112:154713. [Abstract]
- Cell Chem Biol. 2022 Jul 21;29(7):1113-1125.e6. [Abstract]
- Cell Mol Gastroenterol Hepatol. 2022;14(5):1103-1122. [Abstract]
- Cell Rep. 2022 Apr 19;39(3):110698. [Abstract]
- Br J Pharmacol. 2021 Jun;178(12):2443-2460. [Abstract]
- Chin Med. 2025 May 27;20(1):73. [Abstract]
- Front Immunol. 2021 May 19:12:644862. [Abstract]
- Sci Signal. 2021 Jun 22;14(688):eabe6156. [Abstract]
- J Ethnopharmacol. 2026 May 26:121901. [Abstract]
- Food Front. 2025 Oct 7.
- Food Biosci. 2025 Jun.
- Inflamm Res. 2025 Jan 25;74(1):27. [Abstract]
- Cell Biol Toxicol. 2021 Apr;37(2):313-330. [Abstract]
- J Hypertens. 2025 May 1;43(5):827-840. [Abstract]
- Int J Mol Sci. 2023 Mar 27;24(7):6263. [Abstract]
- Int J Mol Sci. 2022 Jan 4;23(1):540. [Abstract]
- Int Immunopharmacol. 2021 Jul:96:107591. [Abstract]
- Int Immunopharmacol. 2020 Jan;78:105931. [Abstract]
- Int J Mol Sci. 2018 Mar 8;19(3). pii: E774. [Abstract]
- Am J Respir Cell Mol Biol. 2025 Feb;72(2):145-157. [Abstract]
- Arthritis Res Ther. 2024 Oct 11;26(1):178. [Abstract]
- Food Sci Nutr. 2022 Jan 18;10(2):564-576. [Abstract]
- Mol Med Rep. 2021 Nov;24(5):783. [Abstract]
- PLoS Pathog. 2020 Jul 17;16(7):e1008664. [Abstract]
- Oncol Rep. 2026 Jun;55(6):110. [Abstract]
- J Dairy Sci. 2020 Dec;103(12):11636-11652. [Abstract]
- J Inflamm Res. 2022 Feb 15;15:1027-1046. [Abstract]
- iScience. 2024 May 16;27(6):110011. [Abstract]
- Neurochem Res. 2022 Feb;47(2):335-346. [Abstract]
- J Virol. 2025 Dec 23;99(12):e0108925. [Abstract]
- BMC Cancer. 2025 Jul 31;25(1):1250. [Abstract]
- Microbiol Spectr. 2023 Aug 17;11(4):e0188823. [Abstract]
- Lab Invest. 2019 Sep;99(9):1321-1334. [Abstract]
- Toxins. 2022 Apr 9;14(4):267. [Abstract]
- Epigenetics. 2023 Dec;18(1):2265625. [Abstract]
- Exp Eye Res. 2023 May:230:109457. [Abstract]
- Front Vet Sci. 2020 Apr 30:7:201. [Abstract]
- Physiol Res. 2026 Mar 11;75(1):63-77. [Abstract]
- PLoS One. 2025 Nov 20;20(11):e0336901. [Abstract]
- Cell Physiol Biochem. 2017;43(5):1855-1865. [Abstract]
- Exp Ther Med. 2020 Aug;20(2):1693-1701. [Abstract]
- Res Sq. 2025 Aug 11.
- Research Square Preprint. 2021 Feb.
Customer Validation & Images
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Bio/Physico-chemical Assay
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Flow Cytometry
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Cell Imaging/Staining
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WB
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WB
Biological Activity
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NF-κB |
IκB-α 10 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | EC50 |
2.6 μM
Compound: 1
|
Cytotoxicity against human A2780 cells co-cultured with human mesothelial cells after 4 hrs by firefly luciferase assay relative to control
Cytotoxicity against human A2780 cells co-cultured with human mesothelial cells after 4 hrs by firefly luciferase assay relative to control
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[PMID: 25581261] |
| A2780 | IC50 |
2.6 μM
Compound: 1, BAY-117085
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Antitumor activity against human A2780 cells co-cultured with mesothelial cell monolayers by firefly luciferase reporter gene assay
Antitumor activity against human A2780 cells co-cultured with mesothelial cell monolayers by firefly luciferase reporter gene assay
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[PMID: 22326395] |
| BXPC-3 | EC50 |
3.5 μM
Compound: 1
|
Cytotoxicity against human BxPC3 cells co-cultured with human mesothelial cells after 4 hrs by firefly luciferase assay relative to control
Cytotoxicity against human BxPC3 cells co-cultured with human mesothelial cells after 4 hrs by firefly luciferase assay relative to control
|
[PMID: 25581261] |
| BXPC-3 | IC50 |
3.7 μM
Compound: 1, BAY-117085
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Antitumor activity against human BxPC3 cells co-cultured with mesothelial cell monolayers by firefly luciferase reporter gene assay
Antitumor activity against human BxPC3 cells co-cultured with mesothelial cell monolayers by firefly luciferase reporter gene assay
|
[PMID: 22326395] |
| DBTRG-05MG | IC50 |
5.53 μM
Compound: 49; BAY 11-7085
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Cytotoxicity against human DBTRG-05MG cells assessed as inhibition of cell viability incubated for 24 hrs by sulforhodamine B assay
Cytotoxicity against human DBTRG-05MG cells assessed as inhibition of cell viability incubated for 24 hrs by sulforhodamine B assay
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[PMID: 36332549] |
| HeLa | IC50 |
0.1 μM
Compound: BAY-117085
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Inhibition of IL-1-alpha-induced NF-kappaB activation in HeLa cells assessed as blocking of p50/p65 nuclear translocation
Inhibition of IL-1-alpha-induced NF-kappaB activation in HeLa cells assessed as blocking of p50/p65 nuclear translocation
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[PMID: 17845850] |
| MDA-MB-231 | IC50 |
4.31 μM
Compound: 49; BAY 11-7085
|
Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell viability incubated for 24 hrs by sulforhodamine B assay
Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell viability incubated for 24 hrs by sulforhodamine B assay
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[PMID: 36332549] |
| SK-OV-3 | EC50 |
5 μM
Compound: 1
|
Cytotoxicity against human SKOV3 cells co-cultured with human mesothelial cells after 4 hrs by firefly luciferase assay relative to control
Cytotoxicity against human SKOV3 cells co-cultured with human mesothelial cells after 4 hrs by firefly luciferase assay relative to control
|
[PMID: 25581261] |
| SK-OV-3 | IC50 |
7.6 μM
Compound: 1, BAY-117085
|
Antitumor activity against human SKOV3 cells co-cultured with mesothelial cell monolayers by firefly luciferase reporter gene assay
Antitumor activity against human SKOV3 cells co-cultured with mesothelial cell monolayers by firefly luciferase reporter gene assay
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[PMID: 22326395] |
BAY 11-7085 inhibits TNFa-induced surface expression of E-selectin, VCAM-1, and ICAM-1with IC50 values in the range of 5-10 μM. BAY 11-7085 stabilizes IκBα in a dose-dependent manner with an IC50 value of approximately 10 μM. There is a clear correlation between the concentration of drug that stabilized IκBα, the concentration that inhibits nuclear levels of NF-kB, and the concentration that inhibits adhesion molecule expression[1].
BAY 11-7085 has been shown to inhibit cell proliferation and induce apoptosis of a variety of cells. BAY 11-7085 (ECSCs) significantly inhibits the cell proliferation and DNA synthesis of ovarian endometriotic cyst stromal cells and induces apoptosis and the G0/G1 phase cell cycle arrest of these cells. BAY 11-7085 induces apoptosis of ECSCs by suppressing antiapoptotic proteins, and that caspase-3-, -8-, and -9-mediated cascades are involved in this mechanism[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 196309-76-9
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Appearance Solid
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분자량 249.33
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화학식 C13H15NO2S
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Color White to off-white
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SMILES
N#C/C=C/S(C(C=C1)=CC=C1C(C)(C)C)(=O)=O
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Synonyms
BAY 11-7083
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (51)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]2025 Dec 15;10(1):406. PMID: 41392286 -
Cancer Cell
Interleukin-1α release during necrotic-like cell death generates myeloid-driven immunosuppression that restricts anti-tumor immunity. [Abstract]2024 Dec 9;42(12):2015-2031.e11. PMID: 39577420 -
Cell Host Microbe
Microbiota-derived urocanic acid triggered by tyrosine kinase inhibitors potentiates cancer immunotherapy efficacy. [Abstract]2025 Jun 11;33(6):915-931.e9. PMID: 40441145 -
Hepatology
A hMTR4-PDIA3P1-miR-125/124-TRAF6 Regulatory Axis and Its Function in NF kappa B Signaling and Chemoresistance. [Abstract]2020 May;71(5):1660-1677. PMID: 31509261 -
Carbohydr Polym
Insights into oral lentinan immunomodulation: Dectin-1-mediated lymphatic transport from Peyer's patch M cells to mononuclear phagocytes. [Abstract]2024 Dec 15:346:122586. PMID: 39245482
BAY 11-7085 purchased from MedChemExpress. Usage Cited in: Carbohydr Polym. 2024 Dec 15:346:122586. [Abstract]
BAY 11-7085 (5 μM/mL; 30 min) in Caco-2 cells showed that the integrity of the monolayer was preserved during inhibitor and FLNT coincubation.
BAY 11-7085 purchased from MedChemExpress. Usage Cited in: Carbohydr Polym. 2024 Dec 15:346:122586. [Abstract]
BAY 11-7085 (5 μM/mL; 30 min) followed by incubation with 200 μg/mL FLNT for 2 h inhibited the uptake of FLNT by 19.7 %. Flow cytometric analysis of the cellular uptake of FLNT by BMDCs treated with Dectin-1/Syk/NF-κB pathway inhibitors.
BAY 11-7085 purchased from MedChemExpress. Usage Cited in: Carbohydr Polym. 2024 Dec 15:346:122586. [Abstract]
BAY 11-7085 (5 μM/mL; 30 min) followed by incubation with 200 μg/mL FLNT for 2 h inhibited the uptake of FLNT by 19.7 %. CLSM images of the cellular uptake of FLNT by BMDCs treated with Dectin-1/Syk/NF-κB pathway inhibitors.
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Cell Death Dis
A small natural molecule CADPE kills residual colorectal cancer cells by inhibiting key transcription factors and translation initiation factors. [Abstract]2020 Nov 15;11(11):982. PMID: 33191401
BAY 11-7085 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2020 Nov 15;11(11):982. [Abstract]
BAY 11-7085 (bay; 20 μM; 48 h) in SW620 cells, Protein levels of the key transcription factors and master regulators in mTOR signaling and its downstream targets, translation initiation factors, anti-apoptotic proteins, and cancer stemness-related proteins.
BAY 11-7085 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2020 Nov 15;11(11):982. [Abstract]
Relative mRNA levels of key transcription factors, master regulators in mTOR signaling and its downstream targets, translation initiation factors, anti-apoptotic proteins, and cancer stemness-related proteins in SW620 cells treated with CADPE (12.5 μM) or FBR for 24 h (n = 3). FBR: a combination of 10058-F4 (30 μM), Bay 11-7085 (20 μM), and Ruxolitinib (20 μM).
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Cell Commun Signal
2025 Nov 13;23(1):496. PMID: 41233873 -
Phytomedicine
Bruceine D suppresses CAF-promoted TNBC metastasis under TNF-α stimulation by inhibiting Notch1-Jagged1/NF-κB(p65) signaling. [Abstract]2024 Jan:123:154928. PMID: 38043386 -
Phytomedicine
Total flavone of flowers of Abelmoschus manihot (L.) Medic inhibits the expression of adhesion molecules in primary mesenteric arterial endothelial cells and ameliorates dextran sodium sulphate-induced ulcerative colitis in mice. [Abstract]2023 Apr:112:154713. PMID: 36857970 -
Cell Chem Biol
Identifying enhancers of innate immune signaling as broad-spectrum antivirals active against emerging viruses. [Abstract]2022 Jul 21;29(7):1113-1125.e6. PMID: 35728599 -
Cell Mol Gastroenterol Hepatol
USP25 Deficiency Exacerbates Acute Pancreatitis via Up-Regulating TBK1-NF-κB Signaling in Macrophages. [Abstract]2022;14(5):1103-1122. PMID: 35934222 -
Cell Rep
Bladder epithelial cell phosphate transporter inhibition protects mice against uropathogenic Escherichia coli infection. [Abstract]2022 Apr 19;39(3):110698. PMID: 35443182 -
Br J Pharmacol
Tectorigenin alleviates intrahepatic cholestasis by inhibiting hepatic inflammation and bile accumulation via activation of PPARγ. [Abstract]2021 Jun;178(12):2443-2460. PMID: 33661551 -
Chin Med
Grain-sized moxibustion activates dendritic cells to enhance the antitumor immunity of cancer vaccines. [Abstract]2025 May 27;20(1):73. PMID: 40426190 -
Front Immunol
Monocarboxylate Transporter 4 Triggered Cell Pyroptosis to Aggravate Intestinal Inflammation in Inflammatory Bowel Disease. [Abstract]2021 May 19:12:644862. PMID: 34093533 -
Sci Signal
TSHZ2 is an EGF-regulated tumor suppressor that binds to the cytokinesis regulator PRC1 and inhibits metastasis. [Abstract]2021 Jun 22;14(688):eabe6156. PMID: 34158398 -
J Ethnopharmacol
Ginsenoside Rg1 restores energy homeostasis in glucolipid metabolic disorders by modulating hypothalamic neuroinflammation. [Abstract]2026 May 26:121901. PMID: 42202919 -
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Inflamm Res
Lipopolysaccharide (LPS) induces sclerostin secretion by extracellular vesicle via TLR4/miR-92a-3p/PTEN/NF-κB signalling pathway in murine macrophage. [Abstract]2025 Jan 25;74(1):27. PMID: 39862242 -
Cell Biol Toxicol
TRPV3 enhances skin keratinocyte proliferation through EGFR-dependent signaling pathways. [Abstract]2021 Apr;37(2):313-330. PMID: 32535744 -
J Hypertens
KAT7 contributes to ponatinib-induced hypertension by promoting endothelial senescence and inflammatory responses through activating NF-κB signaling pathway. [Abstract]2025 May 1;43(5):827-840. PMID: 40084466 -
Int J Mol Sci
iE-DAP Induced Inflammatory Response and Tight Junction Disruption in Bovine Mammary Epithelial Cells via NOD1-Dependent NF-κB and MLCK Signaling Pathway. [Abstract]2023 Mar 27;24(7):6263. PMID: 37047240 -
Int J Mol Sci
Psoriasis-Associated Inflammatory Conditions Induce IL-23 mRNA Expression in Normal Human Epidermal Keratinocytes. [Abstract]2022 Jan 4;23(1):540. PMID: 35008970 -
Int Immunopharmacol
BMP9 promotes methionine- and choline-deficient diet-induced nonalcoholic steatohepatitis in non-obese mice by enhancing NF-κB dependent macrophage polarization. [Abstract]2021 Jul:96:107591. PMID: 33812253 -
Int Immunopharmacol
Secoisolariciresinol diglucoside suppresses Dextran sulfate sodium salt-induced colitis through inhibiting NLRP1 inflammasome. [Abstract]2020 Jan;78:105931. PMID: 31812068 -
Int J Mol Sci
Differential Inflammatory-Response Kinetics of Human Keratinocytes upon Cytosolic RNA- and DNA-Fragment Induction. [Abstract]2018 Mar 8;19(3). pii: E774. PMID: 29518010 -
Am J Respir Cell Mol Biol
Airway Epithelium-derived CXCL14 Promotes Eosinophil Accumulation in Allergic Airway Inflammation. [Abstract]2025 Feb;72(2):145-157. PMID: 39141567 -
Arthritis Res Ther
Methotrexate promotes the release of granulocyte-macrophage colony-stimulating factor from rheumatoid arthritis fibroblast-like synoviocytes via autocrine interleukin-1 signaling. [Abstract]2024 Oct 11;26(1):178. PMID: 39394168 -
Food Sci Nutr
Anti-inflammatory actions of acetate, propionate, and butyrate in fetal mouse jejunum cultures ex vivo and immature small intestinal cells in vitro. [Abstract]2022 Jan 18;10(2):564-576. PMID: 35154692 -
Mol Med Rep
Upregulation of RIP3 promotes necroptosis via a ROS‑dependent NF‑κB pathway to induce chronic inflammation in HK‑2 cells. [Abstract]2021 Nov;24(5):783. PMID: 34498705 -
PLoS Pathog
2020 Jul 17;16(7):e1008664. PMID: 32678826
BAY 11-7085 purchased from MedChemExpress. Usage Cited in: PLoS Pathog. 2020 Jul 17;16(7):e1008664. [Abstract]
HPB-ATL-T, MT-2, MT-4, TL-Om1 cells were treated with BAY11-7085 (2.5, 5 μM) or DMSO for 24 h. Treatment with BAY11-7085 significantly impairs AHR expression in these four cell lines.
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Oncol Rep
NF‑κB‑driven LUZP1 promotes metastasis and chemoresistance in head and neck squamous cell carcinoma. [Abstract]2026 Jun;55(6):110. PMID: 41952496 -
J Dairy Sci
Sodium butyrate promotes lipopolysaccharide-induced innate immune responses by enhancing mitogen-activated protein kinase activation and histone acetylation in bovine mammary epithelial cells. [Abstract]2020 Dec;103(12):11636-11652. PMID: 33010913 -
J Inflamm Res
Aqueous Extract of Cimicifuga dahurica Reprogramming Macrophage Polarization by Activating TLR4-NF-κB Signaling Pathway. [Abstract]2022 Feb 15;15:1027-1046. PMID: 35210810 -
iScience
Transcriptional synergy in human aortic endothelial cells is vulnerable to combination p300/CBP and BET bromodomain inhibition. [Abstract]2024 May 16;27(6):110011. PMID: 38868181 -
Neurochem Res
The Role of NF-κB/NLRP3 Inflammasome Signaling Pathway in Attenuating Pyroptosis by Melatonin Upon Spinal Nerve Ligation Models. [Abstract]2022 Feb;47(2):335-346. PMID: 34515922 -
J Virol
The oncolytic avian reovirus p17 protein triggers chaperone-mediated autophagy by modulating Hsp90 and the T-complex protein-1 ring complex chaperones and co-chaperones to activate the IKK/NF-κB signaling. [Abstract]2025 Dec 23;99(12):e0108925. PMID: 41334925 -
BMC Cancer
Azelaic acid attenuates CCL2/CCR2 axis-mediated skin trafficking of acute myeloid leukemia cells through NF-κB/MAPK signaling modulation in keratinocytes. [Abstract]2025 Jul 31;25(1):1250. PMID: 40745589 -
Microbiol Spectr
Tp47-Induced Monocyte-Derived Microvesicles Promote the Adherence of THP-1 Cells to Human Umbilical Vein Endothelial Cells via an ERK1/2-NF-κB Signaling Cascade. [Abstract]2023 Aug 17;11(4):e0188823. PMID: 37382544 -
Lab Invest
2019 Sep;99(9):1321-1334. PMID: 31019287 -
Toxins
Lipopolysaccharide from the Cyanobacterium Geitlerinema sp. Induces Neutrophil Infiltration and Lung Inflammation. [Abstract]2022 Apr 9;14(4):267. PMID: 35448876 -
Epigenetics
IL-18 serves as a main effector of CAF-derived METTL3 against immunosuppression of NSCLC via driving NF-κB pathway. [Abstract]2023 Dec;18(1):2265625. PMID: 37871286 -
Exp Eye Res
Proteomic characterization of aqueous humor in corneal endothelial decompensation after penetrating keratoplasty. [Abstract]2023 May:230:109457. PMID: 36948439 -
Front Vet Sci
Anti-inflammatory Effect of Astragalin and Chlorogenic Acid on Escherichia coli-Induced Inflammation of Sheep Endometrial Epithelium Cells. [Abstract]2020 Apr 30:7:201. PMID: 32426380 -
Physiol Res
RPS3 Aggravates Sepsis-Induced Acute Kidney Injury Through Activating NF-kappaB Mediated Renal Inflammatory Responses. [Abstract]2026 Mar 11;75(1):63-77. PMID: 41811702 -
PLoS One
Nucleic acid-induced chemokine expression in keratinocytes: Implications for skin inflammation. [Abstract]2025 Nov 20;20(11):e0336901. PMID: 41264606 -
Cell Physiol Biochem
Iridoids with Genipin Stem Nucleus Inhibit Lipopolysaccharide-Induced Inflammation and Oxidative Stress by Blocking the NF-κB Pathway in Polycystic Ovary Syndrome. [Abstract]2017;43(5):1855-1865. PMID: 29049992
BAY 11-7085 purchased from MedChemExpress. Usage Cited in: Cell Physiol Biochem. 2017;43(5):1855-1865. [Abstract]
Elevated SOD activity and HO-1 mRNA expression, and reduced CAT activity induced by LPS are inhibited by BAY 11-7085.
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Exp Ther Med
LncRNA MIR4435-2HG inhibits the progression of osteoarthritis through miR-510-3p sponging. [Abstract]2020 Aug;20(2):1693-1701. PMID: 32742398 -
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용액&용해도
DMSO : 125 mg/mL (501.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : < 0.1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (8.34 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (8.34 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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-
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Protocol
ECSCs cells are incubated for 48 h with BAY 11-7085 (0.01-10 μM). Thereafter, 20 μL of WST-1 dye are added to each well, and the cells are further incubated for 4 h. All experiments are performed in the presence of 10% FBS. Cell proliferation is evaluated by measuring absorbance at 540 nm[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Rats: 1% suspension of carrageenan in distilled water is administered to rats as 0.1 mL subplantar injection into the footpad of the right hind paw. One hour prior to injection, rats are treated intraperitoneally with vehicle (polyethylglycol 400 diluted 1:5 in 5% bovine serum albumin/water) or a fine suspension of compound 2 (1, 5, or 50 mg/kg) in vehicle. A positive control group is also included in which rats are pretreated with 20 mg/kg ibuprofen. Four hours after carrageenan administration, the volume of the injected paw is measured. Edema volumes are determined[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
순도&문서
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Data Sheet (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Pierce JW, et al. Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesionmolecule expression show anti-inflammatory effects in vivo. J Biol Chem. 1997 Aug 22;272(34):21096-103. [Content Brief]
[2]. Nasu K, et al. Application of the nuclear factor-kappaB inhibitor BAY 11-7085 for the treatment of endometriosis: an in vitro study. Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E16-23. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.0107 mL | 20.0537 mL | 40.1075 mL | 100.2687 mL |
| 5 mM | 0.8021 mL | 4.0107 mL | 8.0215 mL | 20.0537 mL | |
| 10 mM | 0.4011 mL | 2.0054 mL | 4.0107 mL | 10.0269 mL | |
| 15 mM | 0.2674 mL | 1.3369 mL | 2.6738 mL | 6.6846 mL | |
| 20 mM | 0.2005 mL | 1.0027 mL | 2.0054 mL | 5.0134 mL | |
| 25 mM | 0.1604 mL | 0.8021 mL | 1.6043 mL | 4.0107 mL | |
| 30 mM | 0.1337 mL | 0.6685 mL | 1.3369 mL | 3.3423 mL | |
| 40 mM | 0.1003 mL | 0.5013 mL | 1.0027 mL | 2.5067 mL | |
| 50 mM | 0.0802 mL | 0.4011 mL | 0.8021 mL | 2.0054 mL | |
| 60 mM | 0.0668 mL | 0.3342 mL | 0.6685 mL | 1.6711 mL | |
| 80 mM | 0.0501 mL | 0.2507 mL | 0.5013 mL | 1.2534 mL | |
| 100 mM | 0.0401 mL | 0.2005 mL | 0.4011 mL | 1.0027 mL |
BAY 11-7085 Related Classifications
HY-10257 Related Classifications
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