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Cat. No.: HY-18080

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SA 47

Name: SA 47
Brand: MedChemExpress
SKU: HY-18080
Availability: PreOrder

1 Cited Publications

고객리뷰

Based on 1 publication(s) in Google Scholar

SA 47 is a selective fatty acid amide hydrolase (FAAH) inhibitor. SA 47 inhibits FAAH enzyme activity and disrupts the NLRP3-FAAH interaction, promoting K48 ubiquitination and selective autophagic degradation of NLRP3. SA 47 reduces NLRP3 protein levels in macrophages. SA 47 can be used for research on inflammatory diseases associated with NLRP3 protein mutations.

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Purity : 99.0%
CAS No.: 792236-07-8
화학식: C₁₇H₂₆N₄O₃
분자량:334.41

보관:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

SA 47 Chemical Structure

CAS No.: 792236-07-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
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Biological Activity

제품 설명

IC₅₀ & Target

FAAH, Carbamate^[1].

All FAAH Isoforms :

In Vitro

InflammasomeOthers

Inflammasome

SA 47 (40 μM) induces NLRP3 protein degradation in BMDMs, reducing NLRP3 protein levels by more than 30%^[1].

Others

SA 47 (10 μM; 30 min) does not inhibit any of the seven cloned rat carboxylesterases in HEK293T cells (X51974/TGH/ES10, NM_031565/ES3, NM_133586/ES2, NM_144743, NM_017004, X81825/ES4, and NM_001024365)^[2].
SA 47 (10 μM; 30 min) does not significantly inhibit carboxylesterase activity in rat liver microsomes or cytosol^[2].
SA 47 shows excellent selectivity for FAAH in both mouse and human tissues, with no significant off-target effects at 10 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Autophagy

Chemical Information

CAS No. 792236-07-8
Appearance Solid
분자량 334.41
화학식 C₁₇H₂₆N₄O₃
Color White to off-white
SMILES

CNC(COC(NCCC(CC1)CCN1C2=CC=CC(C)=N2)=O)=O
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Cell Death Differ

FAAH served a key membrane-anchoring and stabilizing role for NLRP3 protein independently of the endocannabinoid system. [Abstract]

2023 Jan;30(1):168-183. PMID: 36104448

순도&문서

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wen L P, et al. Use of an agent that inhibits or blocks the interaction between FAAH and NLRP3. CN patent, CN115616216A. 2023.

[2]. Zhang D, et al. Fatty acid amide hydrolase inhibitors display broad selectivity and inhibit multiple carboxylesterases as off-targets. Neuropharmacology. 2007 Mar;52(4):1095-105. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
순도&문서
References

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SA 47

Publications Citing Use of MedChemExpress (MCE) SA 47

All FAAH Isoforms