AA76-lipid
AA76-lipid (Compound aa76) is a compound with a C-terminal arginine and histidine. AA76-lipid can be used to prepare pancreas-targeted lipid nanoparticles AH-LNP. After assembling with proteins, the increased size of AH-LNP promotes Capsule-filter-mediated selective accumulation in the pancreas and receptor-mediated endocytosis, thereby enhancing pancreas-targeting ability. AA76-lipid enables highly pancreas-selective delivery of mRNA. AA76-lipid can be used in the research of pancreatic cancer.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- 화학식: C55H101N9O6
- 분자량:984.45
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
Biological Activity
AH-LNP (composed of AA76-lipid) (80 μg/kg; i.p.; single dose) delivers mRNA with high pancreatic selectivity in rats, rabbits, dogs, and pigs, with nearly 90% of bioluminescence signal localized to the pancreas[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
분자량 984.45
-
화학식 C55H101N9O6
-
SMILES
O=C(CCCCCCC/C=C\CCCCCCCC)OCCN(CCOC(CCCCCCC/C=C\CCCCCCCC)=O)CCCNC([C@H](CC1=CNC=N1)NC([C@@H](N)CCCNC(N)=N)=O)=O
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz