AAA-10 formic
Based on 1 publication(s) in Google Scholar
AAA-10 formic is an orally active gut bacterial bile salt hydrolases (BSH) inhibitor, with IC50s of 10 nM, 80 nM against B. theta rBSH and B. longum rBSH, respectively.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- 화학식: C26H43FO7S
- 분자량:518.68
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) AAA-10 formic
More
Biological Activity
IC50: 10 nM (B. theta rBSH), 80 nM (B. longum rBSH)[1]
AAA-10 (100 μM; 24 h) formic inhibits BSH activity in bacterial cultures, with IC50s of 74 nM, 901 nM for Gram-negative and Gram-positive bacteria, respectively[1].
AAA-10 (20 μM; 2 h) formic significantly inhibits deconjugation of glycochenodeoxycholic acid-d4 or taurocholic acid-d4 substrates of human feces[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
AAA-10 (30 mg/kg) formic displays high colonic exposure and low gut permeability[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:10-11 weeks old male C57Bl/6J mice[1]
-
Dosage:30 mg/kg
-
Administration:Orally gavaged once daily for 5 days
-
Result:Decreased the abundances of DCA and LCA in mice feces starting in day 2-5.
Displayed high colonic exposure and low gut permeability.
Chemical Information
-
분자량 518.68
-
화학식 C26H43FO7S
-
SMILES
C[C@H](CCC(CF)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@H](OS(=O)(O)=O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C.O=CO
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Cell Host Microbe
Metabolic immaturity and breastmilk bile acid metabolites are central determinants of heightened newborn vulnerability to norovirus diarrhea. [Abstract]2024 Aug 21:S1931-3128(24)00290-7. PMID: 39214086
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AAA-10 formic Related Classifications
HY-145147A Related Classifications
Powered by Bioz