country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-W1142093

Copy Link Print Information

ActRIIB-IN-4

ActRIIB-IN-4 (Compound 10) is an ActRIIB inhibitor with an IC₅₀ of 4.0 nM. ActRIIB-IN-4 enhances muscle grip strength in tumor cachexia mice.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 3039974-41-6
화학식: C₂₂H₂₃N₅O₂
분자량:389.45

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

ActRIIB-IN-4 Chemical Structure

CAS No.: 3039974-41-6

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

ActRIIB-IN-4 (Compound 10) is an ActRIIB inhibitor with an IC₅₀ of 4.0 nM. ActRIIB-IN-4 enhances muscle grip strength in tumor cachexia mice^[1].

All TGF-β Receptor Isoforms :

In Vitro

ActRIIB-IN-4 (0.625-10 μM) exerts a significant reversing effect on C2C12 myotube atrophy, with a reversal rate of 100.3% at 5 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ActRIIB-IN-4 (10 mg/kg; i.p.) significantly enhances muscle grip strength in C26 tumor cachexia mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3039974-41-6
분자량 389.45
화학식 C₂₂H₂₃N₅O₂
SMILES

C1(C2=CC=C(OCCN3CCOCC3)C=C2)=CN=C(NC=C4C5=NNC=C5)C4=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Dong, et al. 7-azaindole compounds, preparation method therefor, and use thereof. WO2024114661A1. WIPO (PCT). 2023-11-29.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

ActRIIB-IN-4

All TGF-β Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

ActRIIB-IN-4 Related Classifications

HY-W1142093 Related Classifications