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United States

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Cat. No.: HY-178436

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Antituberculosis agent-16

Antituberculosis agent-16 is an orally active antituberculosis agent. Antituberculosis agent-16 exhibits stable antituberculosis activity with a MIC of 0.48 μg/mL against Mycobacterium tuberculosis H37Rv sensitive strain and 0.49 μg/mL against multidrug-resistant strain 14862. Antituberculosis agent-16 shows high Caco-2 permeability. Antituberculosis agent-16 can be used for the research of infection.

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화학식: C₂₃H₂₉N₃O₃
분자량:395.49

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Antituberculosis agent-16 Chemical Structure

사이즈

가격

재고

수량

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- Parmacokinetics
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

Antituberculosis agent-16 shows low cytotoxicity to Vero cells with an IC₅₀ of 37.14 μg/mL^[1].
Antituberculosis agent-16 has high cell membrane permeability with an apparent permeability coefficient (Papp) of 46.1×10^-6 cm/s in Caco-2 assay^[1].
Antituberculosis agent-16 (1-10 μg/mL, 72 h) dose-dependently reduces the intracellular Mycobacterium tuberculosis load in mouse J774A.1 macrophages^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	C_max	T_1/2	MRT_0-t	MRT_0-∞	AUC_0-t	AUC_0-∞	T_max	F
Mice^[1]	5 mg/kg	i.v.	9289 ng/mL	0.22 h	0.2 h	0.2 h	1333 ng·h/mL	1339 ng·h/mL	/	/
Mice^[1]	50 mg/kg	p.o.	923 ng/mL	2.17 h	2.46 h	3.44 h	3480 ng·h/mL	3944 ng·h/mL	0.5-1 ng/mL	29.5 %

Chemical Information

분자량 395.49
화학식 C₂₃H₂₉N₃O₃
SMILES

O=C(C1=CC(C2=CC(OCCOC)=NC=C2)=CN1)N[C@H]3C4CC5C[C@@H](C4)C[C@H]3C5
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wu Y, et al. Optimization of pyrrole-2-carboxamide to develop a potent antituberculosis agent with improved physicochemical property and druggability. Bioorg Chem. 2025 Oct;165:109016. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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