Apoptosis inducer 9
Apoptosis inducer 9 induces apoptosis with IC50 value of 4.21 μM. Apoptosis inducer 9 induces apoptosis through the mitochondrial pathway and enhance the expression of Cl-caspase-3, Cl-caspase-9 and Cl-PARP. Apoptosis inducer 9 can be used the potential to develop new anti-proliferative agents.
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- CAS No.: 2551067-10-6
- 화학식: C34H55N3O4S
- 분자량:601.88
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
Apoptosis inducer 9 (Compound A1) (5-10 μM, 12 hours) induces apoptosis in HepG-2 cells in a concentration-dependent manner[1].
Apoptosis inducer 9 (Compound A1) (0-20 μM, 24 hours) triggers Cl-caspase-3, Cl-caspase-9 and Cl-PARP protein expression in HepG-2, thereby inducing apoptosis[1].
Apoptosis inducer 9 (Compound A1) (0-20 μM, 24 hours) induces apoptosis by triggering the mitochondrial apoptosis pathway[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG-2 cells
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Concentration:5 and 10 μM
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Incubation Time:12 hours
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Result:Apoptotic bodies appeared shrunken, nuclei shrunken and cells fragmented. The apoptosis rates at concentrations of 5 μM and 10 μM were 10.2% and 42.7%, respectively.
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Cell Line:HepG-2 cells
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Concentration:0, 5, 10 and 20 μM
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Incubation Time:24 hours
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Result:Triggered the caspase cascade in HepG-2 and the corresponding protein expression gradually increased.
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Cell Line:HepG-2 cells
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Concentration:0, 5, 10 and 20 μM
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Incubation Time:24 hours
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Result:Induced up-regulation of the expression of Bcl-2, Bax and p53 proteins, and increased the ratio of Bax/Bcl-2.
Chemical Information
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CAS No. 2551067-10-6
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분자량 601.88
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화학식 C34H55N3O4S
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SMILES
C[C@]12[C@@](C[C@H]([C@@]3([H])[C@]2(CC[C@]3([H])[C@@]4(OC(C)(CCC4)C)C)C)O)([H])[C@@]5([C@@](C(C)([C@H](CC5)OC(CSC6=NN=CN6)=O)C)([H])CC1)C
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Apoptosis inducer 9 Related Classifications
HY-147897 Related Classifications
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