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Cat. No.: HY-183649

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BCN-PEG6-OH

BCN-PEG6-OH is a neutralizing agent and anticoagulant inhibitor containing strained alkyne. BCN-PEG6-OH undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) click reaction with azido-Warfarin to generate an inactive product that can be rapidly cleared via the kidneys. In mice, BCN-PEG6-OH effectively reduces the anticoagulant activity of azido-Warfarin in a dose-dependent manner, normalizes prothrombin time, and exhibits no inherent anticoagulant or procoagulant effects when administered alone. BCN-PEG6-OH can be used for the research of drug-induced coagulopathy.

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CAS No.: 2270844-08-9
화학식: C₂₃H₃₉NO₈
분자량:457.56

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

BCN-PEG6-OH Chemical Structure

CAS No.: 2270844-08-9

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

In Vivo

BCN-PEG6-OH (compound 9) (26-52 mg/kg; subcutaneous injection; 2 doses total at 24-hour intervals) dose-dependently neutralizes azido-Warfarin-induced anticoagulant activity in mice, is cleared via the kidneys, and restores prothrombin time (PT) to levels close to those of the vehicle control group^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL6N Mice (male, 8-12 weeks of age, drug-induced coagulopathy model via azido-Warfarin administration)^[1]
Dosage:

26 mg/kg; 52 mg/kg
Administration:

s.c.; 2 doses with 24-hour interval, 5 minutes after each i.p. injection of azido-Warfarin
Result:

Reduced the PT fold change (relative to vehicle) from 3.61 (azido-Warfarin alone) to 2.39.
Reduced the PT fold change from 3.61 to 1.75, a level that was not significantly different from vehicle controls.
Led to in vivo formation of the inactive clicked product 10, with plasma concentrations of free azido-Warfarin dropping below the limit of detection within 60 minutes, and 95.3% of the clicked product recovered in urine indicating rapid renal clearance.

Chemical Information

CAS No. 2270844-08-9
분자량 457.56
화학식 C₂₃H₃₉NO₈
SMILES

C(OC(NCCOCCOCCOCCOCCOCCO)=O)[C@H]1[C@@]2([C@]1(CCC#CCC2)[H])[H]
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Ursuegui S, et al. An in vivo strategy to counteract post-administration anticoagulant activity of azido-Warfarin. Nat Commun. 2017;8:15242. Published 2017 May 19. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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