1222800-79-4
1222800-79-4
Chemical Structure
ML324
- CAS No.: 1222800-79-4
- Formula:C21H23N3O2
- Molecular Weight:349.43
IUPAC Name: N-(3-(dimethylamino)propyl)-4-(8-hydroxyquinolin-6-yl)benzamide
InChIKey: QDBVSOZTVKXUES-UHFFFAOYSA-N
SMILES: O=C(NCCCN(C)C)C1=CC=C(C2=CC(O)=C3N=CC=CC3=C2)C=C1
Biological Activity: ML324 is a potent JMJD2 demethylase inhibitor with antiviral activity. ML324 also exhibits inhibition for the histone demethylase KDM4B, with an IC50 of 4.9 μM. ML324 has potent anti-viral activity against both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection via inhibition viral IE gene expression[1][2].
| Cat. No. | 상품명 | Purity | 제품 설명 | Pricing | |||||||||||||||||||
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ML324 | 98.35% | ML324 is a potent JMJD2 demethylase inhibitor with antiviral activity. ML324 also exhibits inhibition for the histone demethylase KDM4B, with an IC50 of 4.9 μM. ML324 has potent anti-viral activity against both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection via inhibition viral IE gene expression. | ||||||||||||||||||||
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References
- [1]. Rai G, et al. Discovery of ML324, a JMJD2 demethylase inhibitor with demonstrated antiviral activity. [Content Brief]
- [2]. Joy E. Kirkpatrick, et al. Inhibition of the histone demethylase KDM4B leads to activation of KDM1A, attenuates bacterial-induced pro-inflammatory cytokine release, and reduces osteoclastogenesis. Epigenetics. 2018; 13(5): 557–572. [Content Brief]
