53005-05-3
53005-05-3
Chemical Structure
DIDS
Synonym(s): MDL101114ZA free base
- CAS No.: 53005-05-3
- Formula:C16H10N2O6S4
- Molecular Weight:454.52
IUPAC Name: (E)-6,6'-(ethene-1,2-diyl)bis(3-isothiocyanatobenzenesulfonic acid)
InChIKey: YSCNMFDFYJUPEF-OWOJBTEDSA-N
SMILES: O=S(C1=CC(N=C=S)=CC=C1/C=C/C2=CC=C(C=C2S(=O)(O)=O)N=C=S)(O)=O
Biological Activity: DIDS is a dual inhibitor of ABCA1 and VDAC1. DIDS also inhibits RAD51, inhibiting RAD51-mediated homologous pairing and strand exchange reactions. DIDS inhibits anion exchange and binding to red blood cell membranes, inhibits the activation of caspase-3 and -9, and can be used in cancer research[1][2][3][4].
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DIDS | DIDS is a dual inhibitor of ABCA1 and VDAC1. DIDS also inhibits RAD51, inhibiting RAD51-mediated homologous pairing and strand exchange reactions. DIDS inhibits anion exchange and binding to red blood cell membranes, inhibits the activation of caspase-3 and -9, and can be used in cancer research. | |||||||||||||||||||||
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References
- [1]. Ishida T, et, al. DIDS, a chemical compound that inhibits RAD51-mediated homologous pairing and strand exchange. Nucleic Acids Res. 2009 Jun;37(10):3367-76. [Content Brief]
- [2]. Lepke S, et, al. A study of the relationship between inhibition of anion exchange and binding to the red blood cell membrane of 4,4'-diisothiocyano stilbene-2,2'-disulfonic acid (DIDS) and its dihydro derivative (H2DIDS). J Membr Biol. 1976 Oct 20;29(1-2):147-77. [Content Brief]
