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Cat. No.: HY-151105

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CBR Agonist-1

CBR Agonist-1 (27a-cis) is a cannabinoid receptor (CBR) agonist with the K_i values of 0.18 μM for CB₁R and 1.22 μM for CB₂R. CBR Agonist-1 (27a-cis) can be used in the study of endogenous cannabinoid system-related diseases.

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화학식: C₂₇H₂₇FN₄O
분자량:442.53

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

CBR Agonist-1 Chemical Structure

사이즈

가격

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수량

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

rCB1-R

0.18 μM (Ki)

hCB2-R

1.22 μM (Ki)

All Cannabinoid Receptor Isoforms :

In Vitro

CBR Agonist-1 (27a-cis) (24 h) can activate GRABeCB2.0 (fluorescent CB₁R sensor) in a concentration-dependent manner with the EC₅₀ value of 2.1 μM in HEK293T cell lines^[1].
CBR Agonist-1 (27a-cis) (0-10 mM) acts on hCB₁R calcium mobilization with the IC₅₀ value of 3.10 μM in overexpressed hCB₁R CHO-K₁cells^[1].
CBR Agonist-1 (27a-cis) (10-1000 nM, 15 min) induces increased phosphorylation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) in a dose-dependent manner in expressed Gαq16 and hCB₁ CHO cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

분자량 442.53
화학식 C₂₇H₂₇FN₄O
SMILES

O=C(C1=CN(C2=CC=CC=C12)CCCCCF)NCC3=CC=CC=C3/N=N\C4=CC=CC=C4
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Diego A Rodríguez-Soacha, et al. Development of an Indole-Amide-Based Photoswitchable Cannabinoid Receptor Subtype 1 (CB1R) "Cis-On" Agonist. ACS Chem Neurosci. 2022 Jul 26. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
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CBR Agonist-1

All Cannabinoid Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

CBR Agonist-1 Related Classifications

HY-151105 Related Classifications