Men1 - multiple endocrine neoplasia 1 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17283

Summary

Enables DNA-binding transcription activator activity; chromatin binding activity; and transcription cis-regulatory region binding activity. Involved in histone H3-K4 methylation. Acts upstream of or within several processes, including osteoblast development; positive regulation of macromolecule metabolic process; and regulation of osteoblast differentiation. Located in chromosome, telomeric region; cytoplasm; and nucleus. Is expressed in several structures, including 1st branchial arch; alimentary system; central nervous system; gonad; and sensory organ. Used to study growth hormone secreting pituitary adenoma; hyperparathyroidism; multiple endocrine neoplasia type 1; and prolactinoma. Human ortholog(s) of this gene implicated in endocrine gland Cancer (multiple); hyperparathyroidism; and multiple endocrine neoplasia type 1. Orthologous to human MEN1 (menin 1). [provided by Alliance of Genome Resources, Apr 2022]

Men1 Products (4)

mRNA Protein Name
NM_001168488.1 NP_001161960.1 menin isoform a
NM_001168489.1 NP_001161961.1 menin isoform b
NM_001168490.1 NP_001161962.1 menin isoform c
NM_008583.2 NP_032609.1 menin isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
14992727 MGI
enables DNA-binding transcription activator activity IDA
IDA: Inferred from direct assay
14992727 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
15640349 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15150273 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
20956546 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
14992727 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of cell division IMP
IMP: Inferred from mutant phenotype
16195383 MGI
acts upstream of cell population proliferation IDA
IDA: Inferred from direct assay
17975067 MGI
acts upstream of cell population proliferation IGI
IGI: Inferred from genetic interaction
17409423 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
12941803 MGI
acts upstream of or within chromatin remodeling IGI
IGI: Inferred from genetic interaction
16415155 MGI
acts upstream of or within chromatin remodeling IMP
IMP: Inferred from mutant phenotype
15044367 MGI
acts upstream of or within embryo development IMP
IMP: Inferred from mutant phenotype
11158604 MGI
acts upstream of or within embryonic skeletal system morphogenesis IMP
IMP: Inferred from mutant phenotype
17927973 MGI
acts upstream of fibroblast apoptotic process IDA
IDA: Inferred from direct assay
14688275 MGI
acts upstream of fibroblast apoptotic process IGI
IGI: Inferred from genetic interaction
14688275 MGI
acts upstream of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
15640349 MGI
acts upstream of or within hemopoiesis IMP
IMP: Inferred from mutant phenotype
16415155 MGI
acts upstream of or within leukocyte homeostasis IMP
IMP: Inferred from mutant phenotype
16415155 MGI
acts upstream of or within maternal process involved in female pregnancy IDA
IDA: Inferred from direct assay
17975067 MGI
acts upstream of or within negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
15044367 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
11158604 MGI
acts upstream of or within negative regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
15640349 MGI
acts upstream of or within negative regulation of organ growth IDA
IDA: Inferred from direct assay
17975067 MGI
acts upstream of or within negative regulation of osteoblast differentiation IDA
IDA: Inferred from direct assay
15150273 MGI
acts upstream of or within negative regulation of osteoblast differentiation IGI
IGI: Inferred from genetic interaction
15563473 MGI
acts upstream of or within negative regulation of stem cell proliferation IGI
IGI: Inferred from genetic interaction
17409423 MGI
acts upstream of or within negative regulation of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
17927973 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15044367 MGI
acts upstream of or within negative regulation of type B pancreatic cell proliferation IDA
IDA: Inferred from direct assay
17975067 MGI
acts upstream of or within negative regulation of type B pancreatic cell proliferation IMP
IMP: Inferred from mutant phenotype
12941803 MGI
acts upstream of organ growth IDA
IDA: Inferred from direct assay
17975067 MGI
acts upstream of or within ossification IMP
IMP: Inferred from mutant phenotype
17927973 MGI
acts upstream of or within osteoblast development IGI
IGI: Inferred from genetic interaction
15150273 MGI
acts upstream of or within osteoblast fate commitment IGI
IGI: Inferred from genetic interaction
15150273 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
14992727 MGI
acts upstream of or within positive regulation of cell division IMP
IMP: Inferred from mutant phenotype
16195383 MGI
acts upstream of or within positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: Inferred from direct assay
14688275 MGI
acts upstream of or within positive regulation of fibroblast apoptotic process IDA
IDA: Inferred from direct assay
14688275 MGI
acts upstream of or within positive regulation of fibroblast apoptotic process IGI
IGI: Inferred from genetic interaction
14688275 MGI
acts upstream of or within positive regulation of gene expression IDA
IDA: Inferred from direct assay
14992727 MGI
acts upstream of or within positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
16195383 MGI
acts upstream of or within positive regulation of osteoblast differentiation IGI
IGI: Inferred from genetic interaction
15150273 MGI
acts upstream of or within positive regulation of stem cell differentiation IMP
IMP: Inferred from mutant phenotype
17927973 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16195383 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
15150273 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
16415155 MGI
acts upstream of or within regulation of G1/S transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
16740708 MGI
acts upstream of or within regulation of gene expression IDA
IDA: Inferred from direct assay
24824656 MGI
acts upstream of or within roof of mouth development IMP
IMP: Inferred from mutant phenotype
17927973 MGI
acts upstream of stem cell differentiation IMP
IMP: Inferred from mutant phenotype
17927973 MGI
acts upstream of stem cell proliferation IGI
IGI: Inferred from genetic interaction
17409423 MGI
acts upstream of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
17927973 MGI
involved in transcription initiation-coupled chromatin remodeling IMP
IMP: Inferred from mutant phenotype
14992727 MGI
acts upstream of type B pancreatic cell proliferation IDA
IDA: Inferred from direct assay
17975067 MGI
acts upstream of type B pancreatic cell proliferation IMP
IMP: Inferred from mutant phenotype
12941803 MGI
Cellular Component GO Annotation Evidence References Source
located in chromosome, telomeric region IDA
IDA: Inferred from direct assay
12203793 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
9824159 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9824159 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

menin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-151595 Menin-MLL inhibitor-22 Inhibitor 99.85% Unkown
HY-103304 SB 268262 99.9% Unkown
HY-168182 Menin-MLL inhibitor 34 Inhibitor / Unkown
HY-RS08333 MEN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-177140 CDD-1147 Inhibitor / Unkown
HY-RS18140 Men1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24615 Men1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Men1 NCBI NCBI:4221