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Cd274 - CD274 molecule Gene

Also Known as Pdcd1lg1; RGD1566211

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 499342

About Cd274

Primary_assembly 1: 227,116,649-227,134,450 forward strand.mRatBN7.2:CM026974.1

This gene has 1 transcript (splice variant), 102 orthologues, 8 paralogues and is associated with 55 phenotypes. Biased expression in Thymus (RPKM 12.9), Spleen (RPKM 58.3) and 9 other tissues.

Summary

Involved in positive regulation of T cell proliferation and positive regulation of cell migration. Located in cell surface. Biomarker of periodontitis and pre-eclampsia. Orthologous to human CD274 (CD274 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd274 Products (1)

mRNA	Protein	Name
NM_001191954.2	NP_001178883.1	programmed cell death 1 ligand 1 precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	21717117	RGD
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	21717117	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	21717117	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cd274 Protein Structure

0
100
200
290 a.a.

Protein Preferred Names	Protein Names
programmed cell death 1 ligand 1

Recombinant Cd274 Proteins

Cat. No.	상품명	Accession	Purity
HY-P73364	PD-L1 Protein, Rat (HEK293, Fc)	NP_001178883.1 (A18-T238)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73365	PD-L1 Protein, Rat (HEK293, His)	NP_001178883.1 (A18-T238)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (6)

Cat. No.	상품명	효과	Purity	Phase
HY-P99903	Simridarlimab	Inhibitor	99.81%	Phase 2
HY-P990014	Danburstotug	Inhibitor	98.76%	Phase 2
HY-P99698	Lesabelimab	Inhibitor	97.34%	Phase 2
HY-P990623	MDX-1105	Inhibitor	≥99.0%	Phase 1
HY-P991354	GR-1405	Antagonist	/	Phase 1
HY-P991356	FAZ-053	Antagonist	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS02217	CD274 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS02218	Cd274 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS02219	Cd274 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-14243	CEP-14083	Inhibitor	/	Unkown

Inhibitory Antibodies (6)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-P990899	Amostomig		97.931%	Unkown
HY-P991024	Solabafusp alfa	Inhibitor	97.17%	Unkown
HY-P991151	Opamtistomig	Inhibitor	99.69%	Unkown
HY-P991355	PDL-GEX	Antagonist	/	Unkown
HY-P991357	STT-001	Antagonist	/	Unkown
HY-P992385	IMM25011	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cd274	NCBI	NCBI:29126