PTPRF - protein tyrosine phosphatase receptor type F Gene

Also Known as LAR; BNAH2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5792

About PTPRF

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:43,522,051-43,623,666 (from NCBI)

This gene has 16 transcripts (splice variants), 277 orthologues, 35 paralogues and is associated with 3 phenotypes. Broad expression in fat (RPKM 56.2), skin (RPKM 52.7) and 21 other tissues.

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of Insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

PTPRF Products (6)

mRNA Protein Name
NM_001329137.2 NP_001316066.1 receptor-type tyrosine-protein phosphatase F isoform 3 precursor
NM_001329138.2 NP_001316067.1 receptor-type tyrosine-protein phosphatase F isoform 4 precursor
NM_001329139.2 NP_001316068.1 receptor-type tyrosine-protein phosphatase F isoform 5 precursor
NM_001329140.2 NP_001316069.1 receptor-type tyrosine-protein phosphatase F isoform 6 precursor
NM_002840.5 NP_002831.2 receptor-type tyrosine-protein phosphatase F isoform 1 precursor
NM_130440.4 NP_569707.2 receptor-type tyrosine-protein phosphatase F isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables cell adhesion molecule binding IPI
IPI: Inferred from physical interaction
23986473 GOA
enables phosphoprotein phosphatase activity IDA
IDA: Inferred from direct assay
21976490 GOA
enables protein tyrosine phosphatase activity IDA
IDA: Inferred from direct assay
10338209 GOA
enables protein tyrosine phosphatase activity IMP
IMP: Inferred from mutant phenotype
23358419 GOA
Biological Process GO Annotation Evidence References Source
involved in cell migration IMP
IMP: Inferred from mutant phenotype
23358419 GOA
involved in negative regulation of receptor binding IMP
IMP: Inferred from mutant phenotype
23358419 GOA
involved in peptidyl-tyrosine dephosphorylation IMP
IMP: Inferred from mutant phenotype
23358419 GOA
involved in synaptic membrane adhesion IDA
IDA: Inferred from direct assay
26321637 GOA
involved in synaptic membrane adhesion IMP
IMP: Inferred from mutant phenotype
26321637 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPRF Protein Structure

I-set

I-set: Immunoglobulin I-set domain (33 - 124)

I-set

I-set: Immunoglobulin I-set domain (135 - 216)

I-set

I-set: Immunoglobulin I-set domain (232 - 315)

fn3

fn3: Fibronectin type III domain (321 - 401)

fn3

fn3: Fibronectin type III domain (415 - 500)

fn3

fn3: Fibronectin type III domain (514 - 592)

fn3

fn3: Fibronectin type III domain (609 - 696)

fn3

fn3: Fibronectin type III domain (711 - 809)

fn3

fn3: Fibronectin type III domain (832 - 902)

fn3

fn3: Fibronectin type III domain (919 - 1000)

Y_phosphatase

Y_phosphatase: Protein-tyrosine phosphatase (1375 - 1606)

Y_phosphatase

Y_phosphatase: Protein-tyrosine phosphatase (1664 - 1897)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1800
  • 1907 a.a.
Protein Preferred Names Protein Names

receptor-type tyrosine-protein phosphatase F

  • LCA-homolog

PTPRF Antibodies

Cat. No. 상품명 신청 Reactivity
HY-P84047 PTPRF Antibody (YA3744) FC, ELISA Human
HY-P84047A PTPRF Antibody (YA3744)(PBS only) FC, ELISA Human

Related Diseases

Diseases Alias
Breasts And/Or Nipples, Aplasia Or Hypoplasia Of, 2

  • BNAH2

  • Aplasia Or Hypoplasia Of The Breasts And/Or Nipples 2

  • Breasts And/Or Nipples, Aplasia Or Hypoplasia Of, Type 2
Isolated Congenital Breast Hypoplasia/Aplasia

  • Isolated Congenital Amastia
Ureterocele
Pheochromocytoma

  • Pheochromocytoma, Susceptibility To

  • Phaeochromocytoma

  • Adrenal Gland Chromaffin Paraganglioma

  • Adrenal Gland Chromaffinoma

  • Adrenal Gland Paraganglioma

  • Adrenal Gland Pheochromocytoma

  • Chromaffin Paraganglioma Of The Adrenal Gland

  • Intraadrenal Paraganglioma

  • PCC

  • Chromaffin Cell Tumor

  • Medullary Chromaffinoma

  • Medullary Paraganglioma

  • Pheochromoblastoma

  • Pheochromocytomas

  • Chromaffin Cell Neoplasm

  • Pheochromocytoma, Malignant
Van Maldergem Syndrome 1

  • Cerebrofacioarticular Syndrome

  • VMLDS1

  • Van Maldergem Syndrome

  • Cerebro-Facio-Articular Syndrome

  • Van Maldergem Wetzburger Verloes Syndrome
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS11438 PTPRF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17614 Ptprf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24074 Ptprf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PTPRF VGNC VGNC:33550
Macaca mulatta PTPRF VGNC VGNC:76615
Mus musculus PTPRF MGD MGI:102695
Felis catus PTPRF VGNC VGNC:69173
Rattus norvegicus PTPRF RGD RGD:3453
Canis familiaris PTPRF VGNC VGNC:45187
Others PTPRF NCBI