RAB27B - RAB27B, member RAS oncogene family Gene

Also Known as C25KG

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5874

About RAB27B

Cytogenetic location: 18q21.2 Genomic coordinates (GRCh38): 18:54,717,857-54,895,516 (from NCBI)

This gene has 4 transcripts (splice variants), 260 orthologues and 68 paralogues. Biased expression in stomach (RPKM 15.0), prostate (RPKM 9.9) and 13 other tissues.

Summary

Members of the Rab protein family, including RAB27B, are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking (Chen et al., 1997 [PubMed 9066979]).[supplied by OMIM, Nov 2010]

RAB27B Products (2)

mRNA Protein Name
NM_001375327.1 NP_001362256.1 ras-related protein Rab-27B
NM_004163.4 NP_004154.2 ras-related protein Rab-27B

RAB27B Protein Structure

Ras

Ras: Ras family (11 - 182)

  • 0
  • 100
  • 200
  • 218 a.a.
Protein Preferred Names Protein Names

ras-related protein Rab-27B

RAB27B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RAB27B O00194 SYTL5 Homo sapiens Q8TDW5-2
Validated Y2H
32296183
Intra
RAB27B O00194 RPH3A Homo sapiens Q9Y2J0-2
Validated Y2H
32296183
Intra
RAB27B O00194 MYRIP Homo sapiens Q8NFW9
Y2H Prey Pooling
32296183
Intra
RAB27B O00194 MYRIP Homo sapiens Q8NFW9
Validated Y2H
32296183
Intra
RAB27B O00194 MYRIP Homo sapiens Q8NFW9
Y2H Array
32296183
Intra
RAB27B O00194 RPH3AL Homo sapiens Q9UNE2
Validated Y2H
32296183
Intra
RAB27B O00194 RPH3AL Homo sapiens Q9UNE2
Y2H Array
32296183
Intra
RAB27B O00194 SYTL5 Homo sapiens Q8TDW5
Anti Tag CoIP
28514442
Intra
RAB27B O00194 SYTL5 Homo sapiens Q8TDW5
Anti Tag CoIP
33961781
Intra
RAB27B O00194 SYTL5 Homo sapiens Q8TDW5
Y2H Array
31515488
Intra
RAB27B O00194 CAV1 Homo sapiens Q03135
Anti Bait CoIP
19706440
Intra
RAB27B O00194 CAV1 Homo sapiens Q03135
Anti Tag CoIP
19706440
Intra
RAB27B O00194 MLPH Homo sapiens Q9BV36
Anti Tag CoIP
33961781
Intra
RAB27B O00194 MLPH Homo sapiens Q9BV36
Validated Y2H
32296183
Intra
RAB27B O00194 MLPH Homo sapiens Q9BV36
Y2H Prey Pooling
32296183
Intra
RAB27B O00194 MLPH Homo sapiens Q9BV36
Y2H Array
32296183
Intra
RAB27B O00194 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
32296183
Intra
RAB27B O00194 GORASP2 Homo sapiens Q9H8Y8
Y2H Prey Pooling
32296183
Intra
RAB27B O00194 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
32296183
Intra
RAB27B O00194 DHPS Homo sapiens P49366
Y2H Array
32296183
Intra
RAB27B O00194 DHPS Homo sapiens P49366
Y2H Prey Pooling
25416956
Intra
RAB27B O00194 DHPS Homo sapiens P49366
Y2H Prey Pooling
32296183
Intra
RAB27B O00194 DHPS Homo sapiens P49366
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RAB27B Proteins

Cat. No. 상품명 Accession Purity
HY-P75994 RAB27B Protein, Human (HEK293) O00194 (T2-K215) ≥ 85%, as determined by reducing SDS-PAGE.
HY-P75995 RAB27B Protein, Human (HEK293, His) O00194 (T2-K215) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75996 RAB27B Protein, Human (HEK293, Fc) O00194 (T2-K215) ≥ 95%, as determined by reducing SDS-PAGE.

RAB27B Antibodies

Cat. No. 상품명 신청 Reactivity
HY-P83785 RAB27B Antibody (YA3482) IHC-P, FC, ELISA Human
HY-P83785A RAB27B Antibody (YA3482)(PBS only) IHC-P, FC, ELISA Human

Related Diseases

Diseases Alias
Griscelli Syndrome

  • Chediak-Higashi-Like Syndrome

  • Griscelli-Prunieras Syndrome

  • Partial Albinism-Immunodeficiency Syndrome

  • Griscelli Disease

  • Gs

  • Hypopigmentation Immunodeficiency Disease

  • Partial Albinism With Immunodeficiency

  • Immunodeficiency Syndrome With Hypopigmentation

  • Hypopigmentation-Immunodeficiency Disease
Piebald Trait

  • Piebaldism

  • PBT

  • Partial Albinism

  • Albinoidism, Oculocutaneous, Autosomal Dominant
Hermansky-Pudlak Syndrome

  • Hps

  • Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

  • Hermanski-Pudlak Syndrome

  • Hermansky Pudlak Syndrome

  • Platelet Storage Pool Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS11538 RAB27B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-184152 IMP-2552 Inhibitor / Unkown
HY-184153 IMP-2958 / Unkown
HY-RS21183 Rab27b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27699 Rab27b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RAB27B MGD MGI:1931295
Rattus norvegicus RAB27B RGD RGD:620114
Felis catus RAB27B VGNC VGNC:80473
Bos taurus RAB27B VGNC VGNC:33634
Canis familiaris RAB27B VGNC VGNC:45268
Macaca mulatta RAB27B VGNC VGNC:104238
Others RAB27B NCBI