SYTL5 - synaptotagmin like 5 Gene

Also Known as slp5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 94122

About SYTL5

This gene has 2 transcripts (splice variants), 206 orthologues and 31 paralogues. Broad expression in stomach (RPKM 4.3), placenta (RPKM 2.5) and 17 other tissues.

Summary

The protein encoded by this gene belongs to the synaptotagmin-like (Slp) protein family, which contains a unique homology domain at the N-terminus, referred to as the Slp homology domain (SHD). The SHD functions as a binding site for Rab27A, which plays a role in protein transport. Expression of this gene is restricted to placenta and liver, suggesting that it might be involved in Rab27A-dependent membrane trafficking in specific tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

SYTL5 Products (3)

mRNA	Protein	Name
NM_001163334.1	NP_001156806.1	synaptotagmin-like protein 5 isoform 2
NM_001163335.2	NP_001156807.1	synaptotagmin-like protein 5 isoform 1
NM_138780.3	NP_620135.1	synaptotagmin-like protein 5 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12051743	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SYTL5 Protein Structure

FYVE_2

C2

0
200
400
600
730 a.a.

Protein Preferred Names	Protein Names
synaptotagmin-like protein 5	exophilin 9

SYTL5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SYTL5	Q8TDW5	RAB27B	Homo sapiens	O00194	Validated Y2H	25416956
Intra	SYTL5	Q8TDW5	RAB27B	Homo sapiens	O00194	Anti Tag CoIP	33961781
Intra	SYTL5	Q8TDW5	RAB27B	Homo sapiens	O00194	Y2H Prey Pooling	25416956
Intra	SYTL5	Q8TDW5	RAB27B	Homo sapiens	O00194	Y2H Array	25416956
Cross	SYTL5	Q8TDW5	Rab27a	Mus musculus	Q9ERI2	Anti Tag CoIP	12051743
Cross	SYTL5	Q8TDW5	Rab3a	Mus musculus	P63011	Pull Down	12051743
Cross	SYTL5	Q8TDW5	Rab6a	Mus musculus	P35279	Anti Tag CoIP	12051743
Cross	SYTL5	Q8TDW5	Rab6a	Mus musculus	P35279	Pull Down	12051743
Intra	SYTL5	Q8TDW5	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	25416956
Intra	SYTL5	Q8TDW5	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	25416956
Intra	SYTL5	Q8TDW5	WAC	Homo sapiens	Q9BTA9	Y2H Prey Pooling	25416956
Intra	SYTL5	Q8TDW5	WAC	Homo sapiens	Q9BTA9	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14126	SYTL5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SYTL5	RGD	RGD:631342
Macaca mulatta	SYTL5	VGNC	VGNC:78125
Canis familiaris	SYTL5	VGNC	VGNC:47054
Bos taurus	SYTL5	VGNC	VGNC:35549
Mus musculus	SYTL5	MGD	MGI:2668451
Felis catus	SYTL5	VGNC	VGNC:65908
Others	SYTL5	NCBI