Dusp6 - dual specificity phosphatase 6 Gene

Also Known as MKP3; MKP-3; PYST1; 1300019I03Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 67603

Summary

Enables phosphoprotein Phosphatase activity. Acts upstream of or within negative regulation of protein phosphorylation; protein dephosphorylation; and regulation of heart growth. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; embryo ectoderm; embryo mesenchyme; renal cortex; and sensory organ. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 19 with or without anosmia. Orthologous to human DUSP6 (dual specificity Phosphatase 6). [provided by Alliance of Genome Resources, Apr 2022]

Dusp6 Products (1)

mRNA Protein Name
NM_026268.3 NP_080544.1 dual specificity protein phosphatase 6

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables phosphoprotein phosphatase activity IDA
IDA: Inferred from direct assay
15284227 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15284227 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
18753132 MGI
acts upstream of or within protein dephosphorylation IDA
IDA: Inferred from direct assay
15284227 MGI
acts upstream of or within protein dephosphorylation IMP
IMP: Inferred from mutant phenotype
18753132 MGI
acts upstream of or within regulation of heart growth IMP
IMP: Inferred from mutant phenotype
18753132 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dual specificity protein phosphatase 6

  • MAP kinase phosphatase 3

  • mitogen-activated protein kinase phosphatase 3

Dusp6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Dusp6 Q9DBB1 Mapk1 Mus musculus P63085
Phosphatase Assay
16148006
Intra
Dusp6 Q9DBB1 Mapk1 Mus musculus P63085
Y2H
16148006
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-115502 BCI Inhibitor 99.73% Unkown
HY-115502A BCI hydrochloride Inhibitor 99.93% Unkown
HY-168012 Pan-RAS-IN-6 Inhibitor / Unkown
HY-RS04067 DUSP6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-126390 (E/Z)-BCI 99.38% Unkown
HY-181889 KRAS G12C-IN-75 Inhibitor / Unkown
HY-RS17007 Dusp6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23450 Dusp6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dusp6 NCBI NCBI:1848