TSPAN8 - tetraspanin 8 Gene

Also Known as CO-029; TM4SF3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7103

About TSPAN8

Cytogenetic location: 12q21.1 Genomic coordinates (GRCh38): 12:71,125,096-71,157,999 (from NCBI)

This gene has 7 transcripts (splice variants), 217 orthologues and 32 paralogues. Biased expression in colon (RPKM 463.8), duodenum (RPKM 388.7) and 5 other tissues.

Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]

TSPAN8 Products (2)

mRNA Protein Name
NM_001369760.1 NP_001356689.1 tetraspanin-8
NM_004616.3 NP_004607.1 tetraspanin-8

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
27180358 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TSPAN8 Protein Structure

Tetraspannin

Tetraspannin: Tetraspanin family (7 - 234)

  • 0
  • 100
  • 200
  • 237 a.a.
Protein Preferred Names Protein Names

tetraspanin-8

  • transmembrane 4 superfamily member 3

TSPAN8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TSPAN8 P19075 SLC38A7 Homo sapiens Q9NVC3
Validated Y2H
32296183
Intra
TSPAN8 P19075 STX2 Homo sapiens P32856-2
Validated Y2H
32296183
Intra
TSPAN8 P19075 PNLIPRP1 Homo sapiens P54315
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TSPAN8 Proteins

Cat. No. 상품명 Accession Purity
HY-P76117 TSPAN8 Protein, Human (HEK293, His) P19075 (K110-N205) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P76118 TSPAN8 Protein, Human (HEK293, Fc) P19075 (K110-N205) ≥ 95%, as determined by reducing SDS-PAGE.

TSPAN8 Antibodies

Cat. No. 상품명 신청 Reactivity
HY-P84152 TSPAN8 Antibody (YA3849) WB, IHC-P, FC, ELISA Human
HY-P84152A TSPAN8 Antibody (YA3849)(PBS only) WB, IHC-P, FC, ELISA Human

Related Diseases

Diseases Alias
Pancreas, Annular

  • Annular Pancreas

  • Pancreas Annulare

  • Congenital Annular Pancreas
Diabetes Mellitus

  • Diabetes
Maturity-Onset Diabetes Of The Young

  • MODY

  • Maturity Onset Diabetes Mellitus In Young

  • Mason-Type Diabetes

  • Mason Type Diabetes

  • Maturity Onset Diabetes Of The Young

  • Mody Syndrome

  • Diabetes Of The Young, Maturity-Onset
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS15174 TSPAN8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18573 Tspan8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25057 Tspan8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TSPAN8 MGD MGI:2384918
Macaca mulatta TSPAN8 VGNC VGNC:78563
Canis familiaris TSPAN8 VGNC VGNC:47925
Bos taurus TSPAN8 VGNC VGNC:36442
Rattus norvegicus TSPAN8 RGD RGD:621783
Others TSPAN8 NCBI