TMEM88 - transmembrane protein 88 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 92162

About TMEM88

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,855,066-7,856,099 (from NCBI)

This gene has 2 transcripts (splice variants) and 90 orthologues. Broad expression in fat (RPKM 7.7), placenta (RPKM 7.1) and 23 other tissues.

Summary

Predicted to enable PDZ domain binding activity. Involved in negative regulation of canonical Wnt signaling pathway; protein localization to plasma membrane; and protein stabilization. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM88 Products (2)

mRNA Protein Name
NM_001319941.1 NP_001306870.1 transmembrane protein 88 isoform 2
NM_203411.2 NP_981956.1 transmembrane protein 88 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
26359454 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
26359454 GOA
involved in negative regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
21044957 GOA
involved in protein localization to plasma membrane IGI
IGI: Inferred from genetic interaction
21044957 GOA
involved in protein stabilization IGI
IGI: Inferred from genetic interaction
26359454 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
26359454 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
21044957 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transmembrane protein 88

TMEM88 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TMEM88 Q6PEY1 ZDHHC22 Homo sapiens Q8N966
Validated Y2H
32296183
Intra
TMEM88 Q6PEY1 MFF Homo sapiens Q9GZY8-5
Validated Y2H
32296183
Intra
TMEM88 Q6PEY1 VRK2 Homo sapiens Q86Y07
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS14745 TMEM88 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TMEM88 VGNC VGNC:36120
Mus musculus TMEM88 MGD MGI:1914270
Macaca mulatta TMEM88 VGNC VGNC:79922
Felis catus TMEM88 VGNC VGNC:99561
Canis familiaris TMEM88 VGNC VGNC:47611
Rattus norvegicus TMEM88 RGD RGD:1561781
Others TMEM88 NCBI