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Cat. No.: HY-178104

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HDAC-IN-93

HDAC-IN-93 is a HDAC inhibitor with promising total pan-HDAC inhibitory activity. HDAC-IN-93 demonstrates significant broad-spectrum antiproliferative activity across various cancer cell lines. HDAC-IN-93 induces cell apoptosis along with necrosis. HDAC-IN-93 can be used for the studies of prostate cancer and breast cancer.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₁₈H₁₄N₂O₃
분자량:306.32

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

HDAC-IN-93 Chemical Structure

사이즈

가격

재고

수량

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

HDAC6

HDAC7

HDAC8

Bax

Caspase 3

Bcl-2

All HDAC Isoforms :

All Caspase Isoforms :

All Bcl-2 Family Isoforms :

In Vitro

HDAC-IN-93 (Compound 17) is sensitive to a variety of cancer cell lines, with particularly significant effects on prostate cancer PC-3 cells and breast cancer MCF-7 cells with IC₅₀ values of 4.1 μM and 20.8 μM, respectively^[1].
HDAC-IN-93 (4.1 μM, 24 h) causes a significant increase in the number of cells in the SubG0-G1 phase, and induces early apoptosis in MCF-7 cells^[1].
HDAC-IN-93 (4.1 μM, 24 h) upregulates pro-apoptotic genes (Bax, Cyt-C, Caspase-3) and downregulates anti-apoptotic genes (Bcl-2) in MCF-7 cells^[1].
HDAC-IN-93 (4.1 μM, 24 h) shows total HDAC inhibitory activity of 66.1 % at MCF-7 although shows relatively weak direct inhibitory activity against specific HDAC subtypes (6, 7, 8)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:

MCF-7 cells
Concentration:

4.1 μM
Incubation Time:

24 h
Result:

Significant increased the subG0-G1 phase cell population (21.5%).

Apoptosis Analysis^[1]

Cell Line:

MCF-7 cells
Concentration:

4.1 μM
Incubation Time:

24 h
Result:

Induced early apoptosis.

RT-PCR^[1]

Cell Line:

MCF-7 cells
Concentration:

4.1 μM
Incubation Time:

24 h
Result:

Upregulated Bax, Cyt-C and Caspase-3 and downregulated the Bcl-2.

Chemical Information

분자량 306.32
화학식 C₁₈H₁₄N₂O₃
SMILES

N/C(C(C=C1)=CC=C1/C=C/C2=CC(C3=CC=CC=C3O2)=O)=N\O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ashraf R, et al. Design and synthesis of novel Hydroxamate and non-Hydroxamate HDAC inhibitors based on Chromone and Quinazolone scaffolds. Bioorg Chem. 2025 Jul 1;161:108514. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

견적 받기 해외재고보유

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

HDAC-IN-93

All HDAC Isoforms

All Caspase Isoforms

All Bcl-2 Family Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

HDAC-IN-93 Related Classifications

HY-178104 Related Classifications