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Cat. No.: HY-180829

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HDAC6-IN-71

HDAC6-IN-71 (Compound 24) is a HDAC6 inhibitor with IC₅₀ values for HDAC6 and HDAC1 of 13.68 and 443.12 nM respectively. HDAC6-IN-71 effectively inhibits the production of NO by mouse macrophages, with its IC₅₀ being 2.31 μM. HDAC6-IN-71 inhibits the HDAC6-NF-κB signaling pathway, reduces the levels of phosphorylated IκB-α and IKK-α/β, and suppresses the expression of downstream inflammatory proteins COX-2 and iNOS. HDAC6-IN-71 significantly alleviates ulcerative colitis in mice.

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CAS No.: 3062867-16-4
화학식: C₁₈H₁₃NO₅
분자량:323.30

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

HDAC6-IN-71 Chemical Structure

CAS No.: 3062867-16-4

사이즈

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수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

HDAC6

13.68 nM (IC₅₀)

HDAC1

443.12 nM (IC₅₀)

NF-κB

IKK-α

IKK-β

COX-2

iNOS

All HDAC Isoforms :

All NF-κB Isoforms :

All IKK Isoforms :

All COX Isoforms :

All NO Synthase Isoforms :

Chemical Information

CAS No. 3062867-16-4
분자량 323.30
화학식 C₁₈H₁₃NO₅
SMILES

O=C(NO)/C=C/C1=CC=C(C=C1)OC2=CC(OC3=CC=CC=C32)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Qiu X, et al. Design, synthesis and biological evaluation of coumarin-based HDAC6 inhibitors for the treatment of ulcerative colitis. Bioorg Med Chem Lett. 2026 Mar;132:130500. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
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HDAC6-IN-71

All HDAC Isoforms

All NF-κB Isoforms

All IKK Isoforms

All COX Isoforms

All NO Synthase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

HDAC6-IN-71 Related Classifications

HY-180829 Related Classifications