MMV665917
MMV665917 is an orally active piperazine derivative with anti-Cryptosporidium parvum activity with an EC90 of 15 μM. MMV665917 significantly reduces the parasite load in a porcine model infected with C. hominis, decreases ovarian excretion, alleviates diarrhea symptoms and reduces intestinal mucosal damage. MMV665917 can be used for research on Cryptosporidium parvum disease.
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- CAS No.: 904576-65-4
- 화학식: C16H16ClN7O
- 분자량:357.80
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-8 | CC50 |
>100 μM
Compound: 1; MMV665917
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Cytotoxicity against human HCT8 cells assessed as reduction in cell viability after 48 hrs by CellTiter aqueous assay
Cytotoxicity against human HCT8 cells assessed as reduction in cell viability after 48 hrs by CellTiter aqueous assay
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[PMID: 34342443] |
| Huh-7 | CC50 |
>100 μM
Compound: GNF-Pf-3446
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NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)
NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)
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[PMID: 18579783] |
Chemical Information
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CAS No. 904576-65-4
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분자량 357.80
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화학식 C16H16ClN7O
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SMILES
O=C(NC1=CC=C(C([H])=C1)Cl)N2CCN(CC2)C3=NN4C(C=C3)=NN=C4
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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