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Cat. No.: HY-174318

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NARS-3′

NARS-3′ is an orally active reversible xanthine oxidase (XO) inhibitor with the IC₅₀ of 21.01 μM. NARS-3′ can competitively inhibit XO activity and reduce uric acid production. NARS-3′ can reduce renal damage in hyperuricemia mice. NARS-3′ can be used for the study of hyperuricemia.

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CAS No.: 2702589-46-4
화학식: C₁₅H₁₁NaO₈S
분자량:374.30

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

NARS-3′ Chemical Structure

CAS No.: 2702589-46-4

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

NARS-3′ (0-100 μM) exhibits dose-dependent inhibition on XO activity^[1].

NARS-3′ (0-40 μM) can bind to the active site of XO and compete with xanthine substrates during the catalytic process^[1].

NARS-3′ could cause the conformational changes in XO^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NARS-3′ (25-100 mg/kg; i.g.; once daily; for a week) can effectively suppress serum XO activity, reduce serum uric acid (UA) levels in the Potassium oxonate (PO) (HY-17511) induced hyperuricemia mice and exhibits significant protective effects on the kidneys^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Potassium oxonate (250 mg/kg) injected the male Kunming mice (4 weeks)^[1].
Dosage:

0.3 % carboxymethyl cellulose sodium solution
Administration:

Oral gavage (i.g.); once daily for a week
Result:

Reduced serum UA levels to 56.26 μM and reduced XO activity to 9.21 U/L.
Lowered serum CRE levels to 7.85 μM and reduce pathological damage to the kidneys.

Chemical Information

CAS No. 2702589-46-4
분자량 374.30
화학식 C₁₅H₁₁NaO₈S
SMILES

O=C1CC(OC2=CC(O)=CC(O)=C12)C3=CC(S(=O)(O[Na])=O)=C(C=C3)O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Luo Y, et al. Xanthine oxidase inhibitory and anti-hyperuricemic properties of sulfonate derivatives of naringenin. Bioorg Chem. 2025 May 20;163:108618. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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