PF-04822163
PF-04822163 is an orally active, selective, and blood-brain barrier permeable PDE1 inhibitor with IC50 values of 2 nM, 2.4 nM, and 7 nM for PDE1A, PDE1B, and PDE1C respectively. PF-04822163 can be used in the research of attention deficit hyperactivity disorder or Parkinson's disease.
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- CAS No.: 1798334-07-2
- 화학식: C19H17ClN2O2
- 분자량:340.80
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보관:
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Biological Activity
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Chemical Information
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Biological Activity
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PDE1A 2 nM (IC50) |
PDE1B 2.4 nM (IC50) |
PDE1C 7 nM (IC50) |
PDE2A 5895 nM (IC50) |
PDE3A >30000 nM (IC50) |
PDE4D3 7620 nM (IC50) |
PDE5A1 >30000 nM (IC50) |
PDE7B >29800 nM (IC50) |
PDE9A1 >30000 nM (IC50) |
PDE10A1 252 nM (IC50) |
PDE11A4 8257 nM (IC50) |
Pharmacokinetic parameters in rat[1]
| species | route | dose | Tmax(h) | t1/2(h) | fu | B/P | CSF/Pu |
| rat | p.o. | 10 mg/kg | 0.5 | - | 0.028 | 3.4 | 1.7 |