country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-163148

Copy Link Print Information

PHD-IN-3

PHD-IN-3 (Compound 15) is an orally active PHD inhibitor. PHD-IN-3 can be used in the study of anemia associated with chronic kidney disease.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2924181-77-9
화학식: C₂₀H₁₈N₆O₃
분자량:390.40

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

PHD-IN-3 Chemical Structure

CAS No.: 2924181-77-9

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

PHD-IN-3 (Compound 15) is an orally active PHD inhibitor. PHD-IN-3 can be used in the study of anemia associated with chronic kidney disease^[1].

All HIF/HIF Prolyl-Hydroxylase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Hep 3B2	EC₅₀	5 μM Compound: 15	Upregulation of total HIF-1alpha level in human Hep3B cells incubated for 6 hrs by Western blot analysis Upregulation of total HIF-1alpha level in human Hep3B cells incubated for 6 hrs by Western blot analysis	[PMID: 38189253]
Hep 3B2	EC₅₀	6.8 μM Compound: 15	Induction of EPO production in human Hep3B cells incubated for 24 hrs by ELISA Induction of EPO production in human Hep3B cells incubated for 24 hrs by ELISA	[PMID: 38189253]
Hep 3B2	EC₅₀	9 μM Compound: 15	Upregulation of total HIF-2alpha level in human Hep3B cells incubated for 6 hrs by Western blot analysis Upregulation of total HIF-2alpha level in human Hep3B cells incubated for 6 hrs by Western blot analysis	[PMID: 38189253]
Hep 3B2	IC₅₀	>100 μM Compound: 15	Cytotoxicity against human Hep3B cells by CellTiter-Glo assay Cytotoxicity against human Hep3B cells by CellTiter-Glo assay	[PMID: 38189253]

Chemical Information

CAS No. 2924181-77-9
분자량 390.40
화학식 C₂₀H₁₈N₆O₃
SMILES

O[C@@H]1CCN(C1)C2=NC3=C(C(O)=C(N=C3)C(NCC4=CN=C(C=C4)C#N)=O)C=C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xu J, et al. Discovery of Novel and Potent Prolyl Hydroxylase Domain-Containing Protein (PHD) Inhibitors for The Treatment of Anemia. J Med Chem. 2024 Jan 8. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기