Polylactic acid
Based on 1 Customer Validation
Polylactic acid (PLA) is a biodegradable and biocompatible polymer widely used as a carrier for drug delivery systems and a structural material for tissue engineering and medical implants. Polylactic acid acts as a controlled release matrix through the hydrolysis mechanism of ester bonds, gradually releasing the encapsulated drug and metabolizing to non-toxic lactic acid. Polylactic acid has adjustable degradation rate, mechanical properties and the ability to composite with other polymers, and can be used in local or systemic drug delivery, orthopedic fixation devices and 3D printed bone regeneration scaffolds.
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- CAS No.: 26100-51-6
- 화학식: (C3H6O3)x
- 분자량:60000(Average)
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보관:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
26.61 mM
Compound: Lactic acid
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Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
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[PMID: 25299679] |
| MRC5 | IC50 |
23.93 mM
Compound: Lactic acid
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Cytotoxicity against human MRC5 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability after 48 hrs by MTT assay
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[PMID: 25299679] |
Polylactic acid (PLA) showed more efficient release of 5-Fluorouracil (HY-90006) than pure polymer in electrospun hybrid nanofibers of 80:20 PLA/PCL ratio (20 g/L glucose). PLA microspheres (10 mg/mL; 35 days) achieved sustained release of Naltrexone (HY-76711) with a cumulative release rate of 67%. 3D-printed PLA/hydroxyapatite scaffolds (2 weeks in vivo) promoted osteoblast proliferation and bone formation in rabbit calvarial defects. PLA-based drug-eluting scaffolds (10 μg /cm2; 30 days) achieved controlled release of paclitaxel and reduced restenosis rate[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 26100-51-6
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Appearance Solid
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분자량 60000(Average)
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화학식 (C3H6O3)x
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Color White to off-white
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SMILES
O=C(C(C)O)O.[x]
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Synonyms
PLA
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
용액&용해도
DMSO : 200 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
순도&문서
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Data Sheet (268 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Polylactic acid Related Classifications
HY-W250313 Related Classifications
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