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Cat. No.: HY-162920

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QGC583

QGC583 is an effective selective Aminopeptidase A (APA) inhibitor with oral activity and blood-brain barrier permeability, boasting an IC₅₀ value of 4 nM. QGC583 can inhibit APA activity in the brain, kidneys, and heart of rats.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2417001-25-1
화학식: C₁₃H₂₀NO₅P
분자량:301.28

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

QGC583 Chemical Structure

CAS No.: 2417001-25-1

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

IC50: 4 nM (APA)^[1].

All Aminopeptidase Isoforms :

CD13
LTA4H

In Vivo

QGC583 (2 mg/kg; i.v.; single dose) reduces APA activity in the heart, kidneys, and brain of rats by 78%, 66%, and 71% respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Transepithelial/transendothelial electrical resistance assay

Chemical Information

CAS No. 2417001-25-1
분자량 301.28
화학식 C₁₃H₂₀NO₅P
SMILES

O=P([C@@H](N)CCC(O)=O)(O)CCC1=C(OC)C=CC=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Balavoine F, et al. Rational design, synthesis and pharmacological characterization of novel aminopeptidase A inhibitors[J]. Bioorganic & Medicinal Chemistry Letters, 2024, 113: 129940. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
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상품명:
CAS No.:
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Purity:
수량:

QGC583

All Aminopeptidase Isoforms

Biological Activity

제품 설명

IC50 & Target

In Vivo

Chemical Information

순도&문서

References

Calculators

Help & FAQs

QGC583 Related Classifications

HY-162920 Related Classifications

Bioz

Keywords

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