Raluridine
Based on 1 Customer Validation
Raluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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- Purity: 99.53%
- CAS No.: 119644-22-3
- 화학식: C9H10ClFN2O4
- 분자량:264.64
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보관:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CCRF-CEM | CC50 |
188 μM
Compound: 1h; FddClU
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Cytotoxicity in human CEM/0 cells assessed as reduction in cell viability incubated for 4 to 5 days
Cytotoxicity in human CEM/0 cells assessed as reduction in cell viability incubated for 4 to 5 days
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[PMID: 32515595] |
| MT4 | ED50 |
0.38 μM
Compound: 11 (FddClUrd)
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Effective dose achieving 50% protection of MT-4 cells against the cytopathic effect of HIV
Effective dose achieving 50% protection of MT-4 cells against the cytopathic effect of HIV
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[PMID: 2342078] |
| MT4 | ED50 |
0.38 μM
Compound: 17a
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Inhibitory activity against HIV-1 replication in MT-4 cells
Inhibitory activity against HIV-1 replication in MT-4 cells
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[PMID: 2754700] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 119644-22-3
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Appearance Solid
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분자량 264.64
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화학식 C9H10ClFN2O4
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Color White to off-white
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SMILES
OC[C@@H]1[C@@H](F)C[C@H](N2C(NC(C(Cl)=C2)=O)=O)O1
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Synonyms
935U83
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
용액&용해도
DMSO : 250 mg/mL (944.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7787 mL | 18.8936 mL | 37.7872 mL | 94.4680 mL |
| 5 mM | 0.7557 mL | 3.7787 mL | 7.5574 mL | 18.8936 mL | |
| 10 mM | 0.3779 mL | 1.8894 mL | 3.7787 mL | 9.4468 mL | |
| 15 mM | 0.2519 mL | 1.2596 mL | 2.5191 mL | 6.2979 mL | |
| 20 mM | 0.1889 mL | 0.9447 mL | 1.8894 mL | 4.7234 mL | |
| 25 mM | 0.1511 mL | 0.7557 mL | 1.5115 mL | 3.7787 mL | |
| 30 mM | 0.1260 mL | 0.6298 mL | 1.2596 mL | 3.1489 mL | |
| 40 mM | 0.0945 mL | 0.4723 mL | 0.9447 mL | 2.3617 mL | |
| 50 mM | 0.0756 mL | 0.3779 mL | 0.7557 mL | 1.8894 mL | |
| 60 mM | 0.0630 mL | 0.3149 mL | 0.6298 mL | 1.5745 mL | |
| 80 mM | 0.0472 mL | 0.2362 mL | 0.4723 mL | 1.1808 mL | |
| 100 mM | 0.0378 mL | 0.1889 mL | 0.3779 mL | 0.9447 mL |
Raluridine Related Classifications
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