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Cat. No.: HY-139008

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RC363

RC363 is a glutathione peroxidase 1 (GPx1) activator. RC363 enhances glutathione peroxidase activity and inhibits ferroptosis. RC363 can be used for the research of neurodegenerative conditions.

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CAS No.: 2584411-86-7
화학식: C₁₈H₂₄OS₂
분자량:320.51

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

RC363 Chemical Structure

CAS No.: 2584411-86-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

GPX1

All Glutathione Peroxidase Isoforms :

GPX1
GPX4

In Vitro

RC363 (0.0625-3 μM; 1-48 h) inhibits glutamate-induced cytotoxicity in HT-22 cells^[1].
RC363 (3 μM; 6 h) does not significantly decrease oxidant levels in HT-22 cells^[1].
RC363 (3 μM; 24 h) significantly increases the protein level of GPx1 in HT-22 cells^[1].
RC363 (0.0625-1 μM; 24 h) inhibits RSL3 (HY-100218A)-induced ferroptosis in HT-22 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HT-22 cells, primary cortical neurons
Concentration:

3 μM
Incubation Time:

48 h
Result:

Exhibited no cytotoxicity to HT-22 cells.
Inhibited glutamate-induced ferroptosis.

Cell Viability Assay^[1]

Cell Line:

HT-22 cells
Concentration:

0.0625 μM; 0.125 μM; 0.25 μM; 0.5 μM; 1 μM
Incubation Time:

1 h; 2 h; 4 h; 6 h; 8 h
Result:

Exhibited fully protective at the concentration of ≥0.5 μM.
Presented significant protective effects when added simultaneously with glutamate. Gradually lost protection when the compound was added longer periods after the challenge.

Western Blot Analysis^[1]

Cell Line:

HT-22 cells
Concentration:

3 μM
Incubation Time:

24 h
Result:

Significantly increased the protein level of GPx1.

Chemical Information

CAS No. 2584411-86-7
분자량 320.51
화학식 C₁₈H₂₄OS₂
SMILES

OC1=C(C(C)(C)C)C=C(SC2=CC=CS2)C=C1C(C)(C)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bueno DC, et al. New Probucol Analogues Inhibit Ferroptosis, Improve Mitochondrial Parameters, and Induce Glutathione Peroxidase in HT22 Cells. Mol Neurobiol. 2020;57(8):3273-3290. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

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RC363

High-Throughput Bioactive Compound Library

All Glutathione Peroxidase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

RC363 Related Classifications

HY-139008 Related Classifications