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Cat. No.: HY-189941

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SP-835G

SP-835G is a potent Dengue Virus inhibitor with an EC₅₀ of 0.1 μM against DENV2. SP-835G, as a prodrug, is reduced by mitochondrial MARC enzymes to the active metabolite SP-835A, which binds to the allosteric site of NS2B-NS3 protease and blocks both cis and trans cleavage of the protease by restricting the dynamic changes of the helicase subdomain. SP-835G inhibits Dengue virus replication in infected cells with very low cytotoxicity. SP-835G can be used for research on dengue fever.

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화학식: C₂₇H₂₃BrN₈O₃
분자량:587.43

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

SP-835G Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-7	EC₅₀	0.1 μM	Antiviral activity against human HuH7 cells infected with EDEN2 (DENV2) at MOI 0.3 one-hour post infection, measured as EC50 average of two independent experiments. Antiviral activity against human HuH7 cells infected with EDEN2 (DENV2) at MOI 0.3 one-hour post infection, measured as EC50 average of two independent experiments.	slct.74553
Huh-7	CC₅₀	> 100 μM	Cytotoxicity against human HuH7 cells assessed up to 100 μM with CC₅₀ >100 μM. Cytotoxicity against human HuH7 cells assessed up to 100 μM with CC₅₀ >100 μM.	slct.74553

In Vitro

Viral Infection

SP-835G (48 h) significantly inhibits viral replication in DENV2 (EDEN2)-infected HuH-7 cells, with an EC₅₀ of 0.1 μM and very low cytotoxicity (CC₅₀ > 100 μM)^[1].
SP-835G (100 μM) achieves up to 97% viral clearance in BHK-21 cells infected with DENV2 (EDEN2)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

분자량 587.43
화학식 C₂₇H₂₃BrN₈O₃
SMILES

N/C(C1=CC(C2=NC(N(CC3=CC=C(Br)C=C3)C=N4)=C4C(OCC5=CC=CC(/C(N)=N/O)=C5)=N2)=CC=C1)=N\O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Kiousis D, et al. Design and synthesis of a potent, cell active purine-based amidoxime against the dengue virus. ChemistrySelect. 2026.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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